Citations to this article
Abstract
Immune and inflammatory responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contribute to disease severity of coronavirus disease 2019 (COVID-19). However, the utility of specific immune-based biomarkers to predict clinical outcome remains elusive. Here, we analyzed levels of 66 soluble biomarkers in 175 Italian patients with COVID-19 ranging from mild/moderate to critical severity and assessed type I IFN–, type II IFN–, and NF-κB–dependent whole-blood transcriptional signatures. A broad inflammatory signature was observed, implicating activation of various immune and nonhematopoietic cell subsets. Discordance between IFN-α2a protein and IFNA2 transcript levels in blood suggests that type I IFNs during COVID-19 may be primarily produced by tissue-resident cells. Multivariable analysis of patients’ first samples revealed 12 biomarkers (CCL2, IL-15, soluble ST2 [sST2], NGAL, sTNFRSF1A, ferritin, IL-6, S100A9, MMP-9, IL-2, sVEGFR1, IL-10) that when increased were independently associated with mortality. Multivariate analyses of longitudinal biomarker trajectories identified 8 of the aforementioned biomarkers (IL-15, IL-2, NGAL, CCL2, MMP-9, sTNFRSF1A, sST2, IL-10) and 2 additional biomarkers (lactoferrin, CXCL9) that were substantially associated with mortality when increased, while IL-1α was associated with mortality when decreased. Among these, sST2, sTNFRSF1A, IL-10, and IL-15 were consistently higher throughout the hospitalization in patients who died versus those who recovered, suggesting that these biomarkers may provide an early warning of eventual disease outcome.
Authors
Michael S. Abers, Ottavia M. Delmonte, Emily E. Ricotta, Jonathan Fintzi, Danielle L. Fink, Adriana A. Almeida de Jesus, Kol A. Zarember, Sara Alehashemi, Vasileios Oikonomou, Jigar V. Desai, Scott W. Canna, Bita Shakoory, Kerry Dobbs, Luisa Imberti, Alessandra Sottini, Eugenia Quiros-Roldan, Francesco Castelli, Camillo Rossi, Duilio Brugnoni, Andrea Biondi, Laura Rachele Bettini, Mariella D’Angio’, Paolo Bonfanti, Riccardo Castagnoli, Daniela Montagna, Amelia Licari, Gian Luigi Marseglia, Emily F. Gliniewicz, Elana Shaw, Dana E. Kahle, Andre T. Rastegar, Michael Stack, Katherine Myint-Hpu, Susan L. Levinson, Mark J. DiNubile, Daniel W. Chertow, Peter D. Burbelo, Jeffrey I. Cohen, Katherine R. Calvo, John S. Tsang, NIAID COVID-19 Consortium, Helen C. Su, John I. Gallin, Douglas B. Kuhns, Raphaela Goldbach-Mansky, Michail S. Lionakis, Luigi D. Notarangelo
Citation information
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Bouhaddou M, Reuschl AK, Polacco BJ, Thorne LG, Ummadi MR, Ye C, Rosales R, Pelin A, Batra J, Jang GM, Xu J, Moen JM, Richards AL, Zhou Y, Harjai B, Stevenson E, Rojc A, Ragazzini R, Whelan MVX, Furnon W, De Lorenzo G, Cowton V, Syed AM, Ciling A, Deutsch N, Pirak D, Dowgier G, Mesner D, Turner JL, McGovern BL, Rodriguez ML, Leiva-Rebollo R, Dunham AS, Zhong X, Eckhardt M, Fossati A, Liotta NF, Kehrer T, Cupic A, Rutkowska M, Mena I, Aslam S, Hoffert A, Foussard H, Olwal CO, Huang W, Zwaka T, Pham J, Lyons M, Donohue L, Griffin A, Nugent R, Holden K, Deans R, Aviles P, Lopez-Martin JA, Jimeno JM, Obernier K, Fabius JM, Soucheray M, Hüttenhain R, Jungreis I, Kellis M, Echeverria I, Verba K, Bonfanti P, Beltrao P, Sharan R, Doudna JA, Martinez-Sobrido L, Patel AH, Palmarini M, Miorin L, White K, Swaney DL, Garcia-Sastre A, Jolly C, Zuliani-Alvarez L, Towers GJ, Krogan NJ |
Cell | 2023 |
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Noninvasive diagnosis of secondary infections in COVID-19 by sequencing of plasma microbial cell-free DNA
Lisius G, Duttagupta R, Ahmed AA, Hensley M, Al-Yousif N, Lu M, Bain W, Shah F, Blauwkamp TA, Bercovici S, Schaefer C, Qin S, Wang X, Zhang Y, Mitchell KJ, Hughes EK, Jacobs JL, Naqvi A, Haidar G, Mellors JW, Methé B, McVerry BJ, Morris A, Kitsios GD |
iScience | 2023 |
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NLRP3 Inflammasome Involvement in Heart, Liver, and Lung Diseases—A Lesson from Cytokine Storm Syndrome
Napodano C, Carnazzo V, Basile V, Pocino K, Stefanile A, Gallucci S, Natali P, Basile U, Marino M |
International journal of molecular sciences | 2023 |
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The Effect of SARS-CoV-2 Spike Protein RBD-Epitope on Immunometabolic State and Functional Performance of Cultured Primary Cardiomyocytes Subjected to Hypoxia and Reoxygenation
Keturakis V, Narauskaitė D, Balion Z, Gečys D, Kulkovienė G, Kairytė M, Žukauskaitė I, Benetis R, Stankevičius E, Jekabsone A |
International journal of molecular sciences | 2023 |
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Bioinformatics and system biology analysis revealed the crosstalk between COVID‐19 and osteoarthritis
Lai B, Jiang H, Liao T, Gao Y, Zhou X |
Immunity, Inflammation and Disease | 2023 |
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SARS-CoV-2 infection induces expression and secretion of lipocalin-2 and regulates iron in a human lung cancer xenograft model
Park S, Kim D, Kim J, Kwon HJ, Lee Y |
BMB Reports | 2023 |
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Opposing roles for sMAdCAM and IL‐15 in COVID‐19 associated cellular immune pathology
A Singh, N Kasarpalkar, S Bhowmick, G Paradkar, M Talreja, K Shah, A Tiwari, H Palav, S Kaginkar, R Kulkarni, A Patil, V Kalsurkar, S Agrawal, J Shastri, R Dere, R Bharmal, S Mahale, V Bhor, V Patel |
Journal of leukocyte biology | 2022 |
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Treatment with soluble CD24 attenuates COVID-19-associated systemic immunopathology
NJ Song, C Allen, AE Vilgelm, BP Riesenberg, KP Weller, K Reynolds, KB Chakravarthy, A Kumar, A Khatiwada, Z Sun, A Ma, Y Chang, M Yusuf, A Li, C Zeng, JP Evans, D Bucci, M Gunasena, M Xu, NP Liyanage, C Bolyard, M Velegraki, SL Liu, Q Ma, M Devenport, Y Liu, P Zheng, CD Malvestutto, D Chung, Z Li |
Journal of Hematology & Oncology | 2022 |
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Endothelial thrombomodulin downregulation caused by hypoxia contributes to severe infiltration and coagulopathy in COVID-19 patient lungs
T Won, M Wood, D Hughes, M Talor, Z Ma, J Schneider, J Skinner, B Asady, E Goerlich, M Halushka, A Hays, D Kim, C Parikh, A Rosenberg, I Coppens, R Johns, N Gilotra, J Hooper, A Pekosz, D Čiháková |
EBioMedicine | 2022 |
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Regulation of zinc-dependent enzymes by metal carrier proteins
M Thompson |
BioMetals | 2022 |
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Hyperglycemia Induces Inflammatory Response of Human Macrophages to CD163-Mediated Scavenging of Hemoglobin-Haptoglobin Complexes
L Matuschik, V Riabov, C Schmuttermaier, T Sevastyanova, C Weiss, H Klüter, J Kzhyshkowska |
International journal of molecular sciences | 2022 |
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Lymphocyte activation gene-3-associated protein networks are associated with HDL-cholesterol and mortality in the Trans-omics for Precision Medicine program
A Manichaikul, H Lin, C Kang, C Yang, S Rich, K Taylor, X Guo, J Rotter, W Johnson, E Cornell, R Tracy, J Durda, Y Liu, R Vasan, L Cupples, R Gerszten, C Clish, D Jain, M Conomos, T Blackwell, G Papanicolaou, A Rodriguez |
2022 | |
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Longitudinal Plasma Proteomics Analysis Reveals Novel Candidate Biomarkers in Acute COVID-19
Y Mohammed, D Goodlett, M Cheng, D Vinh, T Lee, A Mcgeer, D Sweet, K Tran, T Lee, S Murthy, J Boyd, J Singer, K Walley, D Patrick, C Quan, S Ismail, L Amar, A Pal, R Bassawon, L Fesdekjian, K Gou, F Lamontagne, J Marshall, G Haljan, R Fowler, B Winston, J Russell |
Journal of Proteome Research | 2022 |
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Identification of Parameters Representative of Immune Dysfunction in Patients with Severe and Fatal COVID-19 Infection: a Systematic Review and Meta-analysis
R Qin, L He, Z Yang, N Jia, R Chen, J Xie, W Fu, H Chen, X Lin, R Huang, T Luo, Y Liu, S Yao, M Jiang, J Li |
Clinical Reviews in Allergy & Immunology | 2022 |
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T-Cell Subsets and Interleukin-10 Levels Are Predictors of Severity and Mortality in COVID-19: A Systematic Review and Meta-Analysis
A Alshammary, J Alsughayyir, K Alharbi, A Al-Sulaiman, H Alshammary, H Alshammary |
Frontiers in Medicine | 2022 |
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Quantity of IgG response to SARS-CoV-2 spike glycoprotein predicts pulmonary recovery from COVID-19
M Nairz, S Sahanic, A Pizzini, A Böhm, P Tymoszuk, A Mitterstiller, L von Raffay, P Grubwieser, R Bellmann-Weiler, S Koppelstätter, A Schroll, D Haschka, M Zimmermann, S Blunder, K Trattnig, H Naschberger, W Klotz, I Theurl, V Petzer, C Gehrer, J Mindur, A Luger, C Schwabl, G Widmann, G Weiss, J Löffler-Ragg, I Tancevski, T Sonnweber |
Scientific Reports | 2022 |
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Development of a europium nanoparticles lateral flow immunoassay for NGAL detection in urine and diagnosis of acute kidney injury
M Yin, Y Nie, H Liu, L Liu, L Tang, Y Dong, C Hu, H Wang |
BMC Nephrology | 2022 |
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Cytokine Elevation in Severe COVID-19 From Longitudinal Proteomics Analysis: Comparison With Sepsis
Takeshi Ebihara, Hisatake Matsumoto, Tsunehiro Matsubara, Yuki Togami, Shunichiro Nakao, Hiroshi Matsuura, Takashi Kojima, Fuminori Sugihara, Daisuke Okuzaki, Haruhiko Hirata, Hitoshi Yamamura, Hiroshi Ogura |
Frontiers in immunology | 2022 |
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Matrix metalloproteinases (MMP) 3 and 9 as biomarkers of severity in COVID-19 patients
M Gelzo, S Cacciapuoti, B Pinchera, A Rosa, G Cernera, F Scialò, M Comegna, M Mormile, G Fabbrocini, R Parrella, G Corso, I Gentile, G Castaldo |
Scientific Reports | 2022 |
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SARS-CoV-2 infection in dialysis and kidney transplant patients: immunological and serological response
F Alberici, S Affatato, D Moratto, F Mescia, E Delbarba, A Guerini, M Tedesco, P Burbelo, R Zani, I Castagna, A Gallico, M Tonoli, M Venturini, A Roccaro, M Giacomelli, J Cohen, V Giustini, K Dobbs, H Su, C Fiorini, V Quaresima, F Viola, V Vizzardi, M Gaggiotti, N Bossini, P Gaggia, R Badolato, L Notarangelo, M Chiarini, F Scolari |
Journal of Nephrology | 2022 |
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Early immune responses have long-term associations with clinical, virologic, and immunologic outcomes in patients with COVID-19
Zicheng Hu, Kattria van der Ploeg, Saborni Chakraborty, Prabhu Arunachalam, Diego Mori, Karen Jacobson, Hector Bonilla, Julie Parsonnet, Jason Andrews, Haley Hedlin, Lauren de la Parte, Kathleen Dantzler, Maureen Ty, Gene Tan, Catherine Blish, Saki Takahashi, Isabel Rodriguez-Barraquer, Bryan Greenhouse, Atul Butte, Upinder Singh, Bali Pulendran, Taia Wang, Prasanna Jagannathan |
Research square | 2022 |
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Aortic dissection and Covid-19; a comprehensive systematic review
A Ramandi, M Akbarzadeh, I Khaheshi, M Khalilian |
Current Problems in Cardiology | 2022 |
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An Early Th1 Response Is a Key Factor for a Favorable COVID-19 Evolution
F Gil-Etayo, S Garcinuño, A Utrero-Rico, O Cabrera-Marante, D Arroyo-Sanchez, E Mancebo, D Pleguezuelo, E Rodríguez-Frías, L Allende, P Morales-Pérez, M Castro-Panete, A Lalueza, C Lumbreras, E Paz-Artal, A Serrano |
Biomedicines | 2022 |
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Naïve Human Macrophages Are Refractory to SARS-CoV-2 Infection and Exhibit a Modest Inflammatory Response Early in Infection
Z Zhang, R Penn, W Barclay, E Giotis |
Viruses | 2022 |
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Long-Term Effects of COVID-19
S Joshee, N Vatti, C Chang |
Mayo Clinic Proceedings | 2022 |
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The Association between TNF-α, IL-6, and Vitamin D Levels and COVID-19 Severity and Mortality: A Systematic Review and Meta-Analysis
C Halim, A Mirza, M Sari |
Pathogens | 2022 |
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Stratification of hospitalized COVID-19 patients into clinical severity progression groups by immuno-phenotyping and machine learning
Y Mueller, T Schrama, R Ruijten, M Schreurs, D Grashof, H van de Werken, G Lasinio, D Álvarez-Sierra, C Kiernan, M Eiro, M van Meurs, I Brouwers-Haspels, M Zhao, L Li, H de Wit, C Ouzounis, M Wilmsen, T Alofs, D Laport, T van Wees, G Kraker, M Jaimes, S Bockstael, M Hernández-González, C Rokx, B Rijnders, R Pujol-Borrell, P Katsikis |
Nature Communications | 2022 |
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The Potential Predictive Role of Tumour Necrosis Factor-α, Interleukin-1β, and Monocyte Chemoattractant Protein-1 for COVID-19 Patients Survival
K Kumboyono, I Chomsy, A Iskandar, A Aryati, I Parwati, T Wihastuti |
Infection and drug resistance | 2022 |
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Resistin and IL-15 as Predictors of Invasive Mechanical Ventilation in COVID-19 Pneumonia Irrespective of the Presence of Obesity and Metabolic Syndrome
C Perpiñan, L Bertran, X Terra, C Aguilar, J Binetti, M Lopez-Dupla, A Rull, L Reverté, E Yeregui, F Gómez-Bertomeu, J Peraire, T Auguet |
Journal of Personalized Medicine | 2022 |
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Biomarkers Associated with Cardiovascular Disease in COVID-19
C Kaufmann, A Ahmed, A Burger, M Muthspiel, B Jäger, J Wojta, K Huber |
Cells | 2022 |
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Soluble IL-2R Levels at Baseline Predict the Development of Severe Respiratory Failure and Mortality in COVID-19 Patients
N Gatselis, V Lygoura, A Lyberopoulou, G Giannoulis, A Samakidou, A Vaiou, G Vatidis, K Antoniou, A Stefos, S Georgiadou, D Sagris, D Sveroni, D Stergioula, S Gabeta, G Ntaios, G Dalekos |
Viruses | 2022 |
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The Cause–Effect Dilemma of Hematologic Changes in COVID-19: One Year after the Start of the Pandemic
I Youssry, D Elaziz, N Ayad, I Eyada |
Hematology Reports | 2022 |
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Resolving sticky relationships between platelets and lymphocytes in COVID‐19: A role for checkpoint inhibitors?
Torabi\u2010Parizi P, Suffredini AF |
British Journal of Haematology | 2022 |
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Soluble P2X7 Receptor Is Elevated in the Plasma of COVID-19 Patients and Correlates With Disease Severity
García-Villalba J, Hurtado-Navarro L, Peñín-Franch A, Molina-López C, Martínez-Alarcón L, Angosto-Bazarra D, Baroja-Mazo A, Pelegrin P |
Frontiers in immunology | 2022 |
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Inflammasomes and IL-1 family cytokines in SARS-CoV-2 infection: from prognostic marker to therapeutic agent
Declercq J, De Leeuw E, Lambrecht BN |
Cytokine | 2022 |
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TNF-related apoptosis-inducing ligand, interferon gamma-induced protein 10, and C-reactive protein in predicting the progression of SARS-CoV-2 infection: a prospective cohort study
Tegethoff SA, Danziger G, Kühn D, Kimmer C, Adams T, Heintz L, Metz C, Reifenrath K, Angresius R, Mang S, Rixecker T, Becker A, Geisel J, Jentgen C, Seiler F, Reichert MC, Fröhlich F, Meyer S, Rissland J, Ewen S, Wagenpfeil G, Last K, Smola S, Bals R, Lammert F, Becker SL, Krawczyk M, Lepper PM, Papan C |
International Journal of Infectious Diseases | 2022 |
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Dynamics of circulating calprotectin accurately predict the outcome of moderate COVID-19 patients
Chapuis N, Ibrahimi N, Belmondo T, Goulvestre C, Berger AE, Mariaggi AA, Andrieu M, Chenevier-Gobeaux C, Bayle A, Campos L, Cheurfa C, Chocron R, Diehl JL, Doumenc B, Duchemin J, Duprat M, François F, Gendron N, Mirault T, Pène F, Philippe A, Pommeret F, Sanchez O, Smadja DM, Szwebel TA, Silvin A, Ginhoux F, Lacroix L, Jules-Clément G, Rapeteramana S, Mavier C, Steller L, Perniconi B, André F, Drubay D, Fontenay M, Hüe S, Paul S, Solary E |
EBioMedicine | 2022 |
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A GABA-receptor agonist reduces disease severity, viral load, and death in SARS-CoV-2-infected mice
Jide Tian, Barbara Dillion, Jill Henley, Lucio Comai, Daniel Kaufman |
Frontiers in immunology | 2022 |
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Asymptomatic SARS-CoV-2 Infection Is Associated With Higher Levels of Serum IL-17C, Matrix Metalloproteinase 10 and Fibroblast Growth Factors Than Mild Symptomatic COVID-19
Soares-Schanoski A, Sauerwald N, Goforth CW, Periasamy S, Weir DL, Lizewski S, Lizewski R, Ge Y, Kuzmina NA, Nair VD, Vangeti S, Marjanovic N, Cappuccio A, Cheng WS, Mofsowitz S, Miller CM, Yu XB, George MC, Zaslavsky E, Bukreyev A, Troyanskaya OG, Sealfon SC, Letizia AG, Ramos I |
Frontiers in immunology | 2022 |
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Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19
Sacco K, Castagnoli R, Vakkilainen S, Liu C, Delmonte OM, Oguz C, Kaplan IM, Alehashemi S, Burbelo PD, Bhuyan F, de Jesus AA, Dobbs K, Rosen LB, Cheng A, Shaw E, Vakkilainen MS, Pala F, Lack J, Zhang Y, Fink DL, Oikonomou V, Snow AL, Dalgard CL, Chen J, Sellers BA, Sanchez GA, Barron K, Rey-Jurado E, Vial C, Poli MC, Licari A, Montagna D, Marseglia GL, Licciardi F, Ramenghi U, Discepolo V, Vecchio AL, Guarino A, Eisenstein EM, Imberti L, Sottini A, Biondi A, Mató S, Gerstbacher D, Truong M, Stack MA, Magliocco M, Bosticardo M, Kawai T, Danielson JJ, Hulett T, Askenazi M, Hu S, Cohen JI, Su HC, Kuhns DB, Lionakis MS, Snyder TM, Holland SM, Goldbach-Mansky R, Tsang JS, Notarangelo LD |
Nature Medicine | 2022 |
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Extracorporeal Immunomodulation Treatment and Clinical Outcomes in ICU COVID-19 Patients
Yessayan LT, Neyra JA, Westover AJ, Szamosfalvi B, Humes HD |
2022 | |
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Differential Immune Checkpoint and Ig-like V-Type Receptor Profiles in COVID-19: Associations with Severity and Treatment
Lozano-Rodríguez R, Terrón-Arcos V, López R, Martín-Gutiérrez J, Martín-Quirós A, Maroun-Eid C, del Val EM, Cañada-Illana C, Pascual Iglesias A, Quiroga JV, Montalbán-Hernández K, Casalvilla-Dueñas JC, García-Garrido MA, del Balzo-Castillo Á, Peinado-Quesada MA, Gómez-Lage L, Herrero-Benito C, G. Butler R, Avendaño-Ortiz J, López-Collazo E |
Journal of Clinical Medicine | 2022 |
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Exposing and Overcoming Limitations of Clinical Laboratory Tests in COVID-19 by Adding Immunological Parameters; A Retrospective Cohort Analysis and Pilot Study
Sánchez-Montalvá A, Álvarez-Sierra D, Martínez-Gallo M, Perurena-Prieto J, Arrese-Muñoz I, Ruiz-Rodríguez JC, Espinosa-Pereiro J, Bosch-Nicolau P, Martínez-Gómez X, Antón A, Martínez-Valle F, Riveiro-Barciela M, Blanco-Grau A, Rodríguez-Frias F, Castellano-Escuder P, Poyatos-Canton E, Bas-Minguet J, Martínez-Cáceres E, Sánchez-Pla A, Zurera-Egea C, Teniente-Serra A, Hernández-González M, Pujol-Borrell R |
Frontiers in immunology | 2022 |
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A systems biology approach identifies candidate drugs to reduce mortality in severely ill patients with COVID-19
Fava VM, Bourgey M, Nawarathna PM, Orlova M, Cassart P, Vinh DC, Cheng MP, Bourque G, Schurr E, Langlais D |
Science Advances | 2022 |
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Chemokines, soluble PD-L1, and immune cell hyporesponsiveness are distinct features of SARS-CoV-2 critical illness
Morrell ED, Bhatraju PK, Sathe NA, Lawson J, Mabrey L, Holton SE, Presnell SR, Wiedeman A, Acosta-Vega C, Mitchem MA, Liu T, Chai XY, Sahi S, Brager C, Orlov M, Sakr SS, Sader A, Lum DM, Koetje N, Garay A, Barnes E, Cromer G, Bray MK, Pipavath S, Fink SL, Evans L, Long SA, West TE, Wurfel MM, Mikacenic C |
AJP Lung Cellular and Molecular Physiology | 2022 |
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Considering innate immune responses in SARS-CoV-2 infection and COVID-19
Diamond MS, Lambris JD, Ting JP, Tsang JS |
Nature reviews. Immunology | 2022 |
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Immune Senescence, Immunosenescence and Aging
Lee KA, Flores RR, Jang IH, Saathoff A, Robbins PD |
2022 | |
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Iron and iron-related proteins in COVID-19
Suriawinata E, Mehta KJ |
Clinical and Experimental Medicine | 2022 |
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Abnormal antibodies to self-carbohydrates in SARS-CoV-2-infected patients
Butler DL, Imberti L, Quaresima V, Fiorini C, Gildersleeve JC |
2022 | |
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Cellular therapies for the treatment and prevention of SARS-CoV-2 infection
Conway SR, Keller MD, Bollard CM |
Blood | 2022 |
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Clinical, laboratory data and inflammatory biomarkers at baseline as early discharge predictors in hospitalized SARS-CoV-2 infected patients
Trujillo-Rodriguez M, Muñoz-Muela E, Serna-Gallego A, Praena-Fernández JM, Pérez-Gómez A, Gasca-Capote C, Vitallé J, Peraire J, Palacios-Baena ZR, Cabrera JJ, Ruiz-Mateos E, Poveda E, López-Cortés LE, Rull A, Gutierrez-Valencia A, López-Cortés LF |
PloS one | 2022 |
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Comprehensive Cytokine Profiling of Patients with COVID-19 Receiving Tocilizumab Therapy
Lebedeva A, Molodtsov I, Anisimova A, Berestovskaya A, Dukhin O, Elizarova A, Fitzgerald W, Fomina D, Glebova K, Ivanova O, Kalinskaya A, Lebedeva A, Lysenko M, Maryukhnich E, Misyurina E, Protsenko D, Rosin A, Sapozhnikova O, Sokorev D, Shpektor A, Vorobyeva D, Vasilieva E, Margolis L |
International journal of molecular sciences | 2022 |
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Resistin Associated With Cytokines and Endothelial Cell Adhesion Molecules Is Related to Worse Outcome in COVID-19
Ebihara T, Matsumoto H, Matsubara T, Togami Y, Nakao S, Matsuura H, Onishi S, Kojima T, Sugihara F, Okuzaki D, Hirata H, Yamamura H, Ogura H |
Frontiers in immunology | 2022 |
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Cardiovascular Biomarkers for Prediction of in-hospital and 1-Year Post-discharge Mortality in Patients With COVID-19 Pneumonia
Motloch LJ, Jirak P, Gareeva D, Davtyan P, Gumerov R, Lakman I, Tataurov A, Zulkarneev R, Kabirov I, Cai B, Valeev B, Pavlov V, Kopp K, Hoppe UC, Lichtenauer M, Fiedler L, Pistulli R, Zagidullin N |
Frontiers in Medicine | 2022 |
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Adjunctive Recombinant Human Plasma Gelsolin for Severe Coronavirus Disease 2019 Pneumonia
DiNubile MJ, Parra S, Salomó AC, Levinson SL |
Open Forum Infectious Diseases | 2022 |
|
Innate immunity to SARS-CoV-2 infection: a review
Silva MJ, Rodrigues YC, Lima KV, Lima LN |
Epidemiology and Infection | 2022 |
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Cytokine Storm Signature in Patients with Moderate and Severe COVID-19
Kalinina O, Golovkin A, Zaikova E, Aquino A, Bezrukikh V, Melnik O, Vasilieva E, Karonova T, Kudryavtsev I, Shlyakhto E |
International journal of molecular sciences | 2022 |
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Using patient biomarker time series to determine mortality risk in hospitalised COVID-19 patients: A comparative analysis across two New York hospitals.
Lambert B, Stopard IJ, Momeni-Boroujeni A, Mendoza R, Zuretti A |
PloS one | 2022 |
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The Chemokines CXC, CC and C in the Pathogenesis of COVID-19 Disease and as Surrogates of Vaccine-Induced Innate and Adaptive Protective Responses.
Karimabad MN, Hassanshahi G, Kounis NG, Mplani V, Roditis P, Gogos C, Lagadinou M, Assimakopoulos SF, Dousdampanis P, Koniari I |
Human vaccines | 2022 |
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Combining Deep Phenotyping of Serum Proteomics and Clinical Data via Machine Learning for COVID-19 Biomarker Discovery.
Beltrami AP, De Martino M, Dalla E, Malfatti MC, Caponnetto F, Codrich M, Stefanizzi D, Fabris M, Sozio E, D'Aurizio F, Pucillo CEM, Sechi LA, Tascini C, Curcio F, Foresti GL, Piciarelli C, De Nardin A, Tell G, Isola M |
International journal of molecular sciences | 2022 |
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Circulating microRNA signatures associated with disease severity and outcome in COVID-19 patients.
Giannella A, Riccetti S, Sinigaglia A, Piubelli C, Razzaboni E, Di Battista P, Agostini M, Dal Molin E, Manganelli R, Gobbi F, Ceolotto G, Barzon L |
Frontiers in immunology | 2022 |
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Regulatory T Cells Decreased during Recovery from Mild COVID-19.
Seepathomnarong P, Ongarj J, Sophonmanee R, Seeyankem B, Chusri S, Surasombatpattana S, Pinpathomrat N |
Viruses | 2022 |
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Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19.
Wick KD, Leligdowicz A, Willmore A, Carrillo SA, Ghale R, Jauregui A, Chak SS, Nguyen V, Lee D, Jones C, Dewar R, Lane HC, Kangelaris KN, Hendrickson CM, Liu KD, Sinha P, Erle DJ, Langelier CR, Krummell MF, Woodruff PG, Calfee CS, Matthay MA |
Critical Care | 2022 |
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Immune-inflammatory biomarkers and the risk of cardiac injury in COVID-19 patients with diabetes: a retrospective cohort study
Bo Y, Yuli C, Ye W, Junfeng L, Xiaolin C, Yan B, Zhongyuan W |
Cardiovascular Diabetology | 2022 |
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Vandetanib Blocks the Cytokine Storm in SARS-CoV-2-Infected Mice.
Puhl AC, Gomes GF, Damasceno S, Fritch EJ, Levi JA, Johnson NJ, Scholle F, Premkumar L, Hurst BL, Lee-Montiel F, Veras FP, Batah SS, Fabro AT, Moorman NJ, Yount BL, Dickmander RJ, Baric RS, Pearce KH, Cunha FQ, Alves-Filho JC, Cunha TM, Ekins S |
ACS Omega | 2022 |
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Impact of Innate Immunity, Endothelial Damage, and Metabolic Biomarkers on COVID-19 Severity and Mortality.
Rocco JM, Laghetti P, Di Stefano M, Sereti I, Ortega-Villa A, Wang J, Rupert A, Chironna M, Ye L, Liu X, Anderson MV, Burbelo PB, Fiore JR, Saracino A, Lisco A |
Open Forum Infectious Diseases | 2022 |
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Distribution of Pathogens and Predictive Values of Biomarkers of Inflammatory Response at ICU Admission on Outcomes of Critically Ill COVID-19 Patients with Bacterial Superinfections-Observations from National COVID-19 Hospital in Croatia.
Ćurčić M, Tarle M, Almahariq H, Hleb S, Havaš J, Pražetina M, Lasić H, Dolenc E, Kukoč A, Mihelčić A, Miko I, Romić A, Tipura D, Drmić Ž, Čučković M, Blagaj V, Lukšić I, Peršec J, Šribar A |
2022 | |
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The immune response as a double‐edged sword: The lesson learnt during the COVID‐19 pandemic
Agrati C, Carsetti R, Bordoni V, Sacchi A, Quintarelli C, Locatelli F, Ippolito G, Capobianchi MR |
Immunology | 2022 |
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Respiratory and systemic monocytes, dendritic cells, and myeloid‐derived suppressor cells in COVID‐19: Implications for disease severity
Falck\u2010Jones S, Österberg B, Smed\u2010Sörensen A |
Journal of Internal Medicine | 2022 |
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Clinical utility of circulating calprotectin to assist prediction and monitoring of COVID‐19 severity: An Italian study
Infantino M, Manfredi M, Alessio MG, Previtali G, Grossi V, Benucci M, Faraone A, Fortini A, Grifoni E, Masotti L, Russo E, Amedei A, FitzGerald E, Albesa R, Norman GL, Mahler M |
Journal of Medical Virology | 2022 |
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CXCL8, CCL2, and CMV Seropositivity as New Prognostic Factors for a Severe COVID-19 Course
Pius-Sadowska E, Niedźwiedź A, Kulig P, Baumert B, Sobuś A, Rogińska D, Łuczkowska K, Ulańczyk Z, Wnęk S, Karolak I, Paczkowska E, Kotfis K, Kawa M, Stecewicz I, Zawodny P, Machaliński B |
International journal of molecular sciences | 2022 |
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Early immune markers of clinical, virological, and immunological outcomes in patients with COVID-19: a multi-omics study
Hu Z, van der Ploeg K, Chakraborty S, Arunachalam PS, Mori DA, Jacobson KB, Bonilla H, Parsonnet J, Andrews JR, Holubar M, Subramanian A, Khosla C, Maldonado Y, Hedlin H, de la Parte L, Press K, Ty M, Tan GS, Blish C, Takahashi S, Rodriguez-Barraquer I, Greenhouse B, Butte AJ, Singh U, Pulendran B, Wang TT, Jagannathan P |
eLife | 2022 |
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COVID-19 and Inborn Errors of Immunity.
Delmonte OM, Castagnoli R, Notarangelo LD |
Physiology (Bethesda, Md.) | 2022 |
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Identification and differential usage of a host metalloproteinase entry pathway by SARS-CoV-2 Delta and Omicron.
Benlarbi M, Laroche G, Fink C, Fu K, Mulloy RP, Phan A, Ariana A, Stewart CM, Prévost J, Beaudoin-Bussières G, Daniel R, Bo Y, El Ferri O, Yockell-Lelièvre J, Stanford WL, Giguère PM, Mubareka S, Finzi A, Dekaban GA, Dikeakos JD, Côté M |
iScience | 2022 |
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Adaptive immunity to SARS-CoV-2 infection: A systematic review.
Silva MJA, Ribeiro LR, Lima KVB, Lima LNGC |
Frontiers in immunology | 2022 |
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Calprotectin Levels and Neutrophil Count Are Prognostic Markers of Mortality in COVID-19 Patients.
Cardiero G, Palma D, Vano M, Anastasio C, Pinchera B, Ferrandino M, Gianfico C, Gentile L, Savoia M, Gentile I, Di Taranto MD, Fortunato G |
2022 | |
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Reconstructed Genome-Scale Metabolic Model Characterizes Adaptive Metabolic Flux Changes in Peripheral Blood Mononuclear Cells in Severe COVID-19 Patients.
Tang H, Liu Y, Ruan Y, Ge L, Zhang Q |
International journal of molecular sciences | 2022 |
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High levels of soluble RAGE are associated with a greater risk of mortality in COVID-19 patients treated with dexamethasone
Butcher L, Zaldua JC, Carnicero JA, Hawkins K, Whitley J, Mothukuri R, Evans PA, Morris K, Pillai S, Erusalimsky JD |
Respiratory Research | 2022 |
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Biomarkers of sequela in adult patients convalescing from COVID-19
Suarez VM, Hernandez IC, Hernandez Ramos E, Dominguez GD, Marrero YT, Perez YD, Navarro JM, Perez RB, Simón Pita AM, Rego YD, Morales MM, Sánchez MP, González YZ, Díaz YR, Rojas SA, Díaz IG, Merlín Linares JC, Rodríguez AL, Pérez MR, Caballero OB, Navarro Mariño JA, Elejalde Larrinaga AR, Tamayo CE, Tam Rey LM, Villegas LR, María de la Guardia Peña O, Barcel YJ, Chang Monteagudo A, Lam Díaz RM, Macías Abraham CM |
2022 | |
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Role of cystatin C and calprotectin as potential early prognostic biomarkers in COVID-19 patients admitted to a dedicated COVID care facility
Kumar T, Bhushan D, Kumar S, Jha K, Verma P, Ganguly A, Kumar Y, Zabihullah M |
Journal of Family Medicine and Primary Care | 2022 |
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A 9-mRNA signature measured from whole blood by a prototype PCR panel predicts 28-day mortality upon admission of critically ill COVID-19 patients
Tardiveau C, Monneret G, Lukaszewicz AC, Cheynet V, Cerrato E, Imhoff K, Peronnet E, Bodinier M, Kreitmann L, Blein S, Llitjos JF, Conti F, Gossez M, Buisson M, Yonis H, Cour M, Argaud L, Delignette MC, Wallet F, Dailler F, Monard C, Brengel-Pesce K, Venet F |
Frontiers in immunology | 2022 |
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Exploration of blood−derived coding and non-coding RNA diagnostic immunological panels for COVID-19 through a co-expressed-based machine learning procedure
Zarei Ghobadi M, Emamzadeh R, Teymoori-Rad M, Afsaneh E |
Frontiers in immunology | 2022 |
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Complement activation predicts negative outcomes in COVID-19: The experience from Northen Italian patients.
Meroni PL, Croci S, Lonati PA, Pregnolato F, Spaggiari L, Besutti G, Bonacini M, Ferrigno I, Rossi A, Hetland G, Hollan I, Cugno M, Tedesco F, Borghi MO, Salvarani C |
Autoimmunity Reviews | 2022 |
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Identification of hospitalized mortality of patients with COVID-19 by machine learning models based on blood inflammatory cytokines
Yu Z, Li X, Zhao J, Sun S |
Frontiers in public health | 2022 |
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Supramolecular filaments for concurrent ACE2 docking and enzymatic activity silencing enable coronavirus capture and infection prevention
Anderson CF, Wang Q, Stern D, Leonard EK, Sun B, Fergie KJ, Choi CY, Spangler JB, Villano J, Pekosz A, Brayton CF, Jia H, Cui H |
2022 | |
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Impact of SARS-CoV-2 infection and COVID-19 on patients with inborn errors of immunity
Tangye SG |
Journal of Allergy and Clinical Immunology | 2022 |
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Age and Comorbidities Predict COVID-19 Outcome, Regardless of Innate Immune Response Severity: A Single Institutional Cohort Study.
Mohan AA, Olson LB, Naqvi IA, Morrison SA, Kraft BD, Chen L, Que LG, Ma Q, Barkauskas CE, Kirk A, Nair SK, Sullenger BA, Kasotakis G |
Critical care explorations | 2022 |
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The Association of Low CD4 Expression on Monocytes and Low CD8+ T-Cell Count at Hospital Admission Predicts the Need for Mechanical Ventilation in Patients With COVID-19 Pneumonia: A Prospective Monocentric Cohort Study
Allardet-Servent J, Ait Belkacem I, Miloud T, Benarous L, Galland F, Halfon P, Mège JL, Penaranda G, Busnel JM, Malergue F |
Critical care explorations | 2022 |
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Recent advances of nanotechnology in COVID 19: A critical review and future perspective
Chaudhary KR, Kujur S, Singh K |
2022 | |
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Serum Proteomic Analysis for New Types of Long-Term Persistent COVID-19 Patients in Wuhan.
Li C, Yue L, Ju Y, Wang J, Chen M, Lu H, Liu S, Liu T, Wang J, Hu X, Tuohetaerbaike B, Wen H, Zhang W, Xu S, Jiang C, Chen F |
Microbiology spectrum | 2022 |
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Developing a Novel Immune-Related Seven-Gene Signature and Immune Infiltration Pattern in Patients with COVID-19 and Cardiovascular Disease.
Fu Y, Zhang J, Xu L, Zhang H, Ma S, Gao Y, Jiang Y |
Journal of Cardiovascular Development and Disease | 2022 |
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Can Lactoferrin, a Natural Mammalian Milk Protein, Assist in the Battle against COVID-19?
Einerhand AWC, van Loo-Bouwman CA, Weiss GA, Wang C, Ba G, Fan Q, He B, Smit G |
Nutrients | 2022 |
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Distinct blood inflammatory biomarker clusters stratify host phenotypes during the middle phase of COVID-19.
Blair PW, Brandsma J, Chenoweth J, Richard SA, Epsi NJ, Mehta R, Striegel D, Clemens EG, Alharthi S, Lindholm DA, Maves RC, Larson DT, Mende K, Colombo RE, Ganesan A, Lalani T, Colombo CJ, Malloy AA, Snow AL, Schully KL, Lanteri C, Simons MP, Dumler JS, Tribble D, Burgess T, Pollett S, Agan BK, Clark DV |
Scientific Reports | 2022 |
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Analysis of differential gene expression of pro-inflammatory cytokines in the nasopharyngeal milieu of mild & severe COVID-19 cases.
Ghulam U, Nazim F, Farooqui N, Rizwan-Ul-Hasan S, Anwar MF, Ahmed K, Jamal A, Kayani HA, Mughal N, Hussain A, Sarria-Santamera A, Abidi SH |
PloS one | 2022 |
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Hypoxia Increases the Potential for Neutrophil-mediated Endothelial Damage in Chronic Obstructive Pulmonary Disease.
Lodge KM, Vassallo A, Liu B, Long M, Tong Z, Newby PR, Agha-Jaffar D, Paschalaki K, Green CE, Belchamber KBR, Ridger VC, Stockley RA, Sapey E, Summers C, Cowburn AS, Chilvers ER, Li W, Condliffe AM |
American journal of respiratory and critical care medicine | 2022 |
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A Heterozygous Gain-of-Function Variant in IKBKB Associated with Autoimmunity and Autoinflammation.
Sacco K, Kuehn HS, Kawai T, Alsaati N, Smith L, Davila B, Bundy V, Kuhns DB, Dobbs K, Delmonte O, Notarangelo LD, Rosenzweig SD, Keller MD |
Journal of Clinical Immunology | 2022 |
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Influenza vaccination and single cell multiomics reveal sex dimorphic immune imprints of prior mild COVID-19.
Sparks R, Lau WW, Liu C, Han KL, Vrindten KL, Sun G, Cox M, Andrews SF, Bansal N, Failla LE, Manischewitz J, Grubbs G, King LR, Koroleva G, Leimenstoll S, Snow L, Chen J, Tang J, Mukherjee A, Sellers BA, Apps R, McDermott AB, Martins AJ, Bloch EM, Golding H, Khurana S, Tsang JS |
medRxiv : the preprint server for health sciences | 2022 |
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Immuno-fibrotic drivers of impaired lung function in post-acute sequelae of SARS-CoV-2
Hyung J Chun, Elias Coutavas, Alexander B. Pine, Alfred Lee, Vanessa Yu, Marcus Shallow, Coral X. Giovacchini, Anne M. Mathews, Brian Stephenson, Loretta G. Que, Patty J Lee, Bryan D Kraft |
JCI Insight | 2021 |
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Early Measurement of Blood sST2 Is a Good Predictor of Death and Poor Outcomes in Patients Admitted for COVID-19 Infection
M Sánchez-Marteles, J Rubio-Gracia, N Peña-Fresneda, V Garcés-Horna, B Gracia-Tello, L Martínez-Lostao, S Crespo-Aznárez, JI Pérez-Calvo, I Giménez-López |
Journal of Clinical Medicine | 2021 |
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COVID-19 Impairs Immune Response to Candida albicans
D Moser, K Biere, B Han, M Hoerl, G Schelling, A Choukér, T Woehrle |
Frontiers in immunology | 2021 |
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Kinetics of peripheral blood neutrophils in severe coronavirus disease 2019
M Metzemaekers, S Cambier, M Blanter, J Vandooren, AC Carvalho, B MalengierDevlies, L Vanderbeke, C Jacobs, S Coenen, E Martens, N Pörtner, L Vanbrabant, PV Mol, YV Herck, NV Aerde, G Hermans, J Gunst, A Borin, BT Pereira, AB Gomes, SP Muraro, GF de Souza, AS Farias, JL ProencaModena, MA Vinolo, PE Marques, C Wouters, E Wauters, S Struyf, P Matthys, G Opdenakker, RE Marques, J Wauters, M Gouwy, P Proost, A Wilmer, P Meersseman, D Lambrechts, M Casaer, S Rex, N Lorent, K Thevissen, K Martinod |
IBMS BoneKEy | 2021 |
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Proteomic profiling of MIS-C patients indicates heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunction
C Diorio, R Shraim, LA Vella, JR Giles, AE Baxter, DA Oldridge, SW Canna, SE Henrickson, KO McNerney, F Balamuth, C Burudpakdee, J Lee, T Leng, A Farrel, MP Lambert, KE Sullivan, EJ Wherry, DT Teachey, H Bassiri, EM Behrens |
Nature Communications | 2021 |
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Both Full-Length and Protease-Cleaved Products of Osteopontin Are Elevated in Infectious Diseases
T Hattori, H Iwasaki-Hozumi, G Bai, H Chagan-Yasutan, A Shete, EF Telan, A Takahashi, Y Ashino, T Matsuba |
Biomedicines | 2021 |
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The S100 Protein Family as Players and Therapeutic Targets in Pulmonary Diseases
Z Sattar, A Lora, B Jundi, C Railwah, P Geraghty, K Kuwano |
Pulmonary Medicine | 2021 |
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A novel hypothesis for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorder
AR Sarohan, M Kızıl, AÇ İnkaya, S Mahmud, M Akram, O Cen |
Cellular Signalling | 2021 |
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S100A9 blockade prevents lipopolysaccharide-induced lung injury via suppressing the NLRP3 pathway
B Zhao, R Lu, J Chen, M Xie, X Zhao, L Kong |
Respiratory Research | 2021 |
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Targeting MMP-Regulation of Inflammation to Increase Metabolic Tolerance to COVID-19 Pathologies: A Hypothesis
E Hardy, C Fernandez-Patron |
Biomolecules | 2021 |
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Blood Cytokine Analysis Suggests That SARS-CoV-2 Infection Results in a Sustained Tumour Promoting Environment in Cancer Patients
FH Winter, A Hotterbeekx, MT Huizing, A Konnova, E Fransen, B s Jongers, RK Jairam, VV averbeke, P Moons, E Roelant, DL Blon, WV Berghe, A Janssens, W Lybaert, L Croes, C Vulsteke, S Malhotra-Kumar, H Goossens, Z Berneman, M Peeters, PA van Dam, S Kumar-Singh |
Cancers | 2021 |
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Elevated Expression Levels of Lung Complement Anaphylatoxin, Neutrophil Chemoattractant Chemokine IL-8, and RANTES in MERS-CoV-Infected Patients: Predictive Biomarkers for Disease Severity and Mortality
ME Hamed, A Naeem, H Alkadi, AA Alamri, AS AlYami, A AlJuryyan, W Alturaiki, M Enani, ST Al-Shouli, AM Assiri, B Alosaimi |
Journal of Clinical Immunology | 2021 |
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Involvement of Interleukin-1 Receptor-Associated Kinase 4 and Interferon Regulatory Factor 5 in the Immunopathogenesis of SARS-CoV-2 Infection: Implications for the Treatment of COVID-19
N Stoy |
Frontiers in immunology | 2021 |
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COVID-19 in Children: Expressions of Type I/II/III Interferons, TRIM28, SETDB1, and Endogenous Retroviruses in Mild and Severe Cases
PA Tovo, S Garazzino, V Daprà, G Pruccoli, C Calvi, F Mignone, C Alliaudi, M Denina, C Scolfaro, M Zoppo, F Licciardi, U Ramenghi, I Galliano, M Bergallo |
International journal of molecular sciences | 2021 |
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AI-guided discovery of the invariant host response to viral pandemics
D Sahoo, GD Katkar, S Khandelwal, M Behroozikhah, A Claire, V Castillo, C Tindle, MK Fuller, S Taheri, TF Rogers, N Beutler, SI Ramirez, SA Rawlings, V Pretorius, DM Smith, DR Burton, LE Alexander, J Duran, S Crotty, JM Dan, S Das, P Ghosh |
EBioMedicine | 2021 |
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Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19
C Liu, AJ Martins, WW Lau, N Rachmaninoff, J Chen, L Imberti, D Mostaghimi, DL Fink, PD Burbelo, K Dobbs, OM Delmonte, N Bansal, L Failla, A Sottini, E Quiros-Roldan, KL Han, BA Sellers, F Cheung, R Sparks, TW Chun, S Moir, MS Lionakis, C Rossi, HC Su, DB Kuhns, JI Cohen, LD Notarangelo, JS Tsang, MS Abers, R Apps, M Bosticardo, P Milanez-Almeida, MP Mulè, E Shaw, Y Zhang, F Castelli, ML Muiesan, G Tomasoni, F Scolari, A Tucci |
Cell | 2021 |
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Phillyrin for COVID-19 and Influenza Co-infection: A Potential Therapeutic Strategy Targeting Host Based on Bioinformatics Analysis
Y Lai, T Han, Z Lao, G Li, J Xiao, X Liu |
Frontiers in pharmacology | 2021 |
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An Impaired Inflammatory and Innate Immune Response in COVID-19
SH Park |
Molecules and Cells | 2021 |
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BTK inhibitors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): A systematic review
M Stack, K Sacco, R Castagnoli, AA Livinski, LD Notarangelo, MS Lionakis |
Clinical Immunology | 2021 |
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BTK inhibitors for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): A Systematic Review
Michael Stack, Keith Sacco, Riccardo Castagnoli, Alicia A Livinski, Luigi D Notarangelo, Michail S Lionakis |
Research square | 2021 |
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High dimensional profiling identifies specific immune types along the recovery trajectories of critically ill COVID19 patients
PA Penttilä, SV Gassen, D Panovska, L Vanderbeke, YV Herck, K Quintelier, A Emmaneel, J Filtjens, B Malengier-Devlies, K Ahmadzadeh, PV Mol, DM Borràs, A Antoranz, FM Bosisio, E Wauters, K Martinod, P Matthys, Y Saeys, AD Garg, J Wauters, FD Smet |
Cellular and Molecular Life Sciences | 2021 |
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C-C motive chemokine ligand 2 and thromboinflammation in COVID-19-associated pneumonia: A retrospective study
D Nieri, T Neri, G Barbieri, S Moneta, G Morelli, D Mingardi, S Spinelli, L Ghiadoni, M Falcone, G Tiseo, F Menichetti, M Franzini, L Caponi, A Paolicchi, R Pancani, F Pistelli, L Carrozzi, A Celi |
Thrombosis Research | 2021 |
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The cytokine storm in COVID-19: Further advances in our understanding the role of specific chemokines involved
F Coperchini, L Chiovato, G Ricci, L Croce, F Magri, M Rotondi |
Cytokine & Growth Factor Reviews | 2021 |
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COVID-19 Modulates Inflammatory and Renal Markers That May Predict Hospital Outcomes among African American Males
W Fonseca, N Asai, K Yagi, CA Malinczak, G Savickas, CC Johnson, S Murray, EM Zoratti, NW Lukacs, J Li, CF Schuler |
Viruses | 2021 |
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Elevated cytokines and chemokines in peripheral blood of patients with SARS-CoV-2 pneumonia treated with high-titer convalescent plasma
SL Fanning, R Korngold, Z Yang, K Goldgirsh, S Park, J Zenreich, M Baker, P McKiernan, M Tan, B Zhang, ML Donato, DS Perlin, SR Shih |
PLoS pathogens | 2021 |
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Immune profiling of COVID-19: preliminary findings and implications for the pandemic
HT Maecker |
Journal for ImmunoTherapy of Cancer | 2021 |
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Clinical Relevance of Elevated Soluble ST2, HSP27 and 20S Proteasome at Hospital Admission in Patients with COVID-19
R Wendt, MT Lingitz, M Laggner, M Mildner, D Traxler, A Graf, P Krotka, B Moser, K Hoetzenecker, S Kalbitz, C Lübbert, J Beige, HJ Ankersmit |
Biology : open access journal | 2021 |
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The Combined Use of Cytokine Serum Values with Laboratory Parameters Improves Mortality Prediction of COVID-19 Patients: The Interleukin-15-to-Albumin Ratio
SA Rizo-Téllez, LA Méndez-García, AC Rivera-Rugeles, M Miranda-García, AN Manjarrez-Reyna, R Viurcos-Sanabria, H Solleiro-Villavicencio, E Becerril-Villanueva, JD Carrillo-Ruíz, JM Cota-Arce, A Álvarez-Lee, MA León-Nava, G Escobedo |
Microorganisms | 2021 |
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Biomarkers of Post-COVID Depression
P Lorkiewicz, N Waszkiewicz |
Journal of Clinical Medicine | 2021 |
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Cytokine Profiles Associated With Worse Prognosis in a Hospitalized Peruvian COVID-19 Cohort
MJ Pons, B Ymaña, A Mayanga-Herrera, Y Sáenz, L Alvarez-Erviti, S Tapia-Rojas, R Gamarra, AB Blanco, G Moncunill, MF Ugarte-Gil |
Frontiers in immunology | 2021 |
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Chronic Obstructive Pulmonary Disease Patients Have Increased Levels of Plasma Inflammatory Mediators Reported Upregulated in Severe COVID-19
N Acevedo, JM Escamilla-Gil, H Espinoza, R Regino, J Ramírez, LF de Arco, R Dennis, CA Torres-Duque, L Caraballo |
Frontiers in immunology | 2021 |
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Impact of the Innate Inflammatory Response on ICU Admission and Death in Hospitalized Patients with COVID-19
J Monserrat, A Asunsolo, A Gómez-Lahoz, MA Ortega, JM Gasalla, Ó Gasulla, J Fortuny-Profitós, FA Mazaira-Font, MT Román, A Arranz, J Sanz, B Muñoz, J Arévalo-Serrano, JM Rodríguez, C Martínez-A, D Balomenos, M Álvarez-Mon |
Biomedicines | 2021 |
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Differential Co-Expression Network Analysis Reveals Key Hub-High Traffic Genes as Potential Therapeutic Targets for COVID-19 Pandemic
A Hasankhani, A Bahrami, N Sheybani, B Aria, B Hemati, F Fatehi, HG Farahani, G Javanmard, M Rezaee, JP Kastelic, HW Barkema |
Frontiers in immunology | 2021 |
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The intersection of COVID-19 and autoimmunity: What is our current understanding?
NE Winchester, C Calabrese, L Calabrese |
Pathogens and Immunity | 2021 |
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Discrimination of COVID‐19 From Inflammation‐Induced Cytokine Storm Syndromes Using Disease‐Related Blood Biomarkers
C Kessel, R Vollenberg, K Masjosthusmann, C Hinze, H Wittkowski, F Debaugnies, C Nagant, F Corazza, F Vély, G Kaplanski, C GirardGuyonvarch, C Gabay, H Schmidt, D Foell, PR Tepasse |
Arthritis & Rheumatology | 2021 |
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Deep learning identifies antigenic determinants of severe SARS-CoV-2 infection within T-cell repertoires
JW Sidhom, AS Baras |
Scientific Reports | 2021 |
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Circulating Calprotectin as a Biomarker of COVID-19 Severity
M Mahler, PL Meroni, M Infantino, KA Buhler, MJ Fritzler |
Expert Review of Clinical Immunology | 2021 |
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Immunomodulation and Reduction of Thromboembolic Risk in Hospitalized COVID-19 Patients: Systematic Review and Meta-Analysis of Randomized Trials
D Sagris, M Florentin, P Tasoudis, E Korompoki, N Gatselis, EJ Giamarellos-Bourboulis, H Milionis, J Douketis, AC Spyropoulos, G Dalekos, G Ntaios |
Journal of Clinical Medicine | 2021 |
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Acute Lung Injury Biomarkers in the Prediction of COVID-19 Severity: Total Thiol, Ferritin and Lactate Dehydrogenase
AM Mesa, EC César, E Martín-Montañez, ES Alvarez, PM Lopez, Y Romero-Zerbo, M Garcia-Fernandez, JL Garrido |
Antioxidants | 2021 |
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SARS-CoV-2 infection in the Syrian hamster model causes inflammation as well as type I interferon dysregulation in both respiratory and non-respiratory tissues including the heart and kidney
ME Francis, U Goncin, A Kroeker, C Swan, R Ralph, Y Lu, AL Etzioni, D Falzarano, V Gerdts, S Machtaler, J Kindrachuk, AA Kelvin, A Pekosz |
PLoS pathogens | 2021 |
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Cytokine/Chemokine Expression Is Closely Associated Disease Severity of Human Adenovirus Infections in Immunocompetent Adults and Predicts Disease Progression
J Li, J Wei, Z Xu, C Jiang, M Li, J Chen, Y Li, M Yang, Y Gu, F Wang, Y Shu, Y Yang, L Sun, Y Liu |
Frontiers in immunology | 2021 |
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Neutralizing type‐I interferon autoantibodies are associated with delayed viral clearance and intensive care unit admission in patients with COVID‐19
MS Abers, LB Rosen, OM Delmonte, E Shaw, P Bastard, L Imberti, V Quaresima, A Biondi, P Bonfanti, R Castagnoli, JL Casanova, HC Su, LD Notarangelo, SM Holland, MS Lionakis |
Immunology and Cell Biology | 2021 |
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Distinct clinical and immunological profiles of patients with evidence of SARS-CoV-2 infection in sub-Saharan Africa
B Morton, KG Barnes, C Anscombe, K Jere, P Matambo, J Mandolo, R Kamngona, C Brown, J Nyirenda, T Phiri, NP Banda, CV Veer, KS Mndolo, K Mponda, J Rylance, C Phiri, J Mallewa, M Nyirenda, G Katha, P Kambiya, J Jafali, HC Mwandumba, SB Gordon, J Phulusa, M Mkandawire, S Kaimba, H Thole, S Nthala, E Nsomba, L Keyala, P Mandala, B Chinoko, M Gmeiner, V Kaudzu, S Lissauer, B Freyne, P MacPherson, TD Swarthout, PY Tam, S Sichone, A Ahmadu, O Kanjewa, V Nyasulu, E Chinyama, A Zuza, B Denis, E Storey, N Bondera, D Matchado, A Chande, A Chingota, C Ntwea, L Mkandawire, C Mhango, A Lakudzala, M Chaponda, P Mwenechanya, L Mvaya, D Tembo, MY Henrion, J Chirombo, C Masesa, J Gondwe, J Cornick, KC Jambo |
Nature Communications | 2021 |
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COVID-19 Severity Potentially Modulated by Cardiovascular-Disease-Associated Immune Dysregulation
AC Lee, G Castaneda, WT Li, C Chen, N Shende, J Chakladar, PR Taub, EY Chang, WM Ongkeko |
Viruses | 2021 |
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A Novel Modified-Curcumin Promotes Resolvin-Like Activity and Reduces Bone Loss in Diabetes-Induced Experimental Periodontitis
J Deng, LM Golub, HM Lee, V Raja, F Johnson, A Kucine, W Lee, TM Xu, Y Gu |
Journal of inflammation research | 2021 |
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Aspirin Is Related to Worse Clinical Outcomes of COVID-19
I Kim, S Yoon, M Kim, H Lee, S Park, W Kim, S Lee |
Medicina | 2021 |
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Divergent COVID-19 Disease Trajectories Predicted by a DAMP-Centered Immune Network Model
JD Day, S Park, BL Ranard, H Singh, CC Chow, Y Vodovotz |
Frontiers in immunology | 2021 |
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Clonal hematopoiesis in patients with Covid‐19 is stable and not linked to an aggravated clinical course
V Petzer, S Schwendinger, D Haschka, V Vogi, P Tymoszuk, F Burkert, S Sahanic, T Sonnweber, R BellmannWeiler, J LoefflerRagg, I Tancevski, J Zschocke, G Weiss, D Wolf, E Jukic |
American Journal of Hematology | 2021 |
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Immune Signature Linked to COVID-19 Severity: A SARS-Score for Personalized Medicine
J Russick, PE Foy, N Josseaume, M Meylan, NB Hamouda, A Kirilovsky, CE Sissy, E Tartour, DM Smadja, A Karras, JS Hulot, M Livrozet, A Fayol, JB Arlet, JL Diehl, MA Dragon-Durey, F Pagès, I Cremer |
Frontiers in immunology | 2021 |
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IL-6 and IL-10 are associated with disease severity and higher comorbidity in adults with COVID-19
RL Luporini, JM de A. Rodolpho, LT Kubota, AC Martin, MR Cominetti, F de Freitas Anibal, H Pott-Junior |
Cytokine | 2021 |
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Aging whole blood transcriptome reveals candidate genes for SARS-CoV-2-related vascular and immune alterations
LG de Almeida Chuffa, PP Freire, J dos Santos Souza, MC de Mello, M de Oliveira Neto, RF Carvalho |
Journal of Molecular Medicine | 2021 |
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A urinary peptidomic profile predicts outcome in SARS-CoV-2-infected patients
R Wendt, L Thijs, S Kalbitz, H Mischak, J Siwy, J Raad, J Metzger, B Neuhaus, H von der Leyen, E Dudoignon, A Mebazaa, G Spasovski, M Milenkova, A Canevska-Talevska, B Czerwieńska, A Wiecek, B Peters, Å Nilsson, M Schwab, K Rothfuss, C Lübbert, JA Staessen, J Beige |
2021 | |
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Interferons and other cytokines, genetics and beyond in COVID-19 and autoimmunity
G Opdenakker, JV Damme |
Cytokine & Growth Factor Reviews | 2021 |
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Soluble Suppression of Tumorigenicity-2 Associates With Ventilator Dependence in Coronavirus Disease 2019 Respiratory Failure
JW Alladina, FL Giacona, EB White, KL Brait, EA Abe, SA Michelhaugh, KA Hibbert, JL Januzzi, BT Thompson, JL Cho, BD Medoff |
2021 | |
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SARS-CoV-2: Pathogenesis, Molecular Targets and Experimental Models
G Kanimozhi, B Pradhapsingh, CS Pawar, HA Khan, SH Alrokayan, NR Prasad |
Frontiers in pharmacology | 2021 |
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Comprehensive Analysis of the Systemic Transcriptomic Alternations and Inflammatory Response during the Occurrence and Progress of COVID-19
S Mo, L Dai, Y Wang, B Song, Z Yang, W Gu, V Jakovljevic |
Oxidative Medicine & Cellular Longevity | 2021 |
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Recombinant human plasma gelsolin (rhu-pGSN) in a patient hospitalized with critical COVID-19 pneumonia
JV Catteeuw, MJ DiNubile |
2021 | |
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A Dynamic Bayesian Model for Identifying High-Mortality Risk in Hospitalized COVID-19 Patients
A Momeni-Boroujeni, R Mendoza, IJ Stopard, B Lambert, A Zuretti |
Infectious disease reports | 2021 |
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Lessons from pathophysiology: Use of individualized combination treatments with immune interventional agents to tackle severe respiratory failure in patients with COVID-19
GN Dalekos, A Stefos, S Georgiadou, V Lygoura, A Michail, G Ntaios, A Samakidou, G Giannoulis, S Gabeta, M Vlychou, E Petinaki, K Leventogiannis, EJ Giamarellos-Bourboulis, NK Gatselis |
European Journal of Internal Medicine | 2021 |
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Effect of anti-interleukin drugs in patients with COVID-19 and signs of cytokine release syndrome (COV-AID): a factorial, randomised, controlled trial
J Declercq, KF Damme, ED Leeuw, B Maes, C Bosteels, SJ Tavernier, SD Buyser, R Colman, M Hites, G Verschelden, T Fivez, F Moerman, IK Demedts, N Dauby, ND Schryver, E Govaerts, SJ Vandecasteele, JV Laethem, S Anguille, J van der Hilst, B Misset, H Slabbynck, X Wittebole, F Liénart, C Legrand, M Buyse, D Stevens, F Bauters, LJ Seys, H Aegerter, U Smole, V Bosteels, L Hoste, L Naesens, F Haerynck, L Vandekerckhove, P Depuydt, E van Braeckel, S Rottey, I Peene, CV Straeten, F Hulstaert, BN Lambrecht |
The lancet. Respiratory medicine | 2021 |
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Bioinformatics approach to identify common gene signatures of patients with coronavirus 2019 and lung adenocarcinoma
X Liang, Y Chen, Y Fan |
Environmental Science and Pollution Research | 2021 |
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MMP-2 and MMP-9 levels in plasma are altered and associated with mortality in COVID-19 patients
C DAvila-Mesquita, AE Couto, LC Campos, TF Vasconcelos, J Michelon-Barbosa, CA Corsi, F Mestriner, BC Petroski-Moraes, MJ Garbellini-Diab, DM Couto, MC Jordani, D Ferro, L Sbragia, EE Joviliano, PR Evora, R de Carvalho Santana, OA Martins-Filho, K Polonis, MG Menegueti, MS Ribeiro, M Auxiliadora-Martins, C Becari |
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie | 2021 |
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Angiotensin System Modulations in Spontaneously Hypertensive Rats and Consequences on Erythrocyte Properties; Action of MLN-4760 and Zofenopril
T Jasenovec, D Radosinska, M Kollarova, P Balis, E Dayar, I Bernatova, S Zorad, N Vrbjar, S Cacanyova, J Radosinska |
Biomedicines | 2021 |
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Blunted sFasL signalling exacerbates TNF‐driven neutrophil necroptosis in critically ill COVID‐19 patients
TA Schweizer, SM Shambat, C Vulin, S Hoeller, C Acevedo, M Huemer, A GomezMejia, CC Chang, J Baum, S Hertegonne, E Hitz, TC Scheier, DA Hofmaenner, PK Buehler, H Moch, RA Schuepbach, SD Brugger, AS Zinkernagel |
IBMS BoneKEy | 2021 |
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Immunothrombosis Biomarkers for Distinguishing Coronavirus Disease 2019 Patients From Noncoronavirus Disease Septic Patients With Pneumonia and for Predicting ICU Mortality
E Cani, D Dwivedi, K Liaw, D Fraser, C Yeh, C Martin, M Slessarev, S Cerroni, A Fox-Robichaud, J Weitz, P Kim, P Liaw |
2021 | |
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Unveiling a Hidden Biomarker of Inflammation and Tumor Progression: The 65 kDa Isoform of MMP-9 New Horizons for Therapy
Rossano R, Larocca M, Macellaro M, Bilancia D, Riccio P |
Current issues in molecular biology | 2021 |
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Soluble TNF receptors predict acute kidney injury and mortality in critically ill COVID-19 patients: A prospective observational study
Sancho Ferrando E, Hanslin K, Hultström M, Larsson A, Frithiof R, Lipcsey M |
Cytokine | 2021 |
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Lessons learned: new insights on the role of cytokines in COVID-19
Buszko M, Nita-Lazar A, Park JH, Schwartzberg PL, Verthelyi D, Young HA, Rosenberg AS |
Nature Immunology | 2021 |
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In depth analysis of patients with severe SARS-CoV-2 in sub-Saharan Africa demonstrates distinct clinical and immunological profiles.
Morton B, Barnes KG, Anscombe C, Jere K, Kamng'ona R, Brown C, Nyirenda J, Phiri T, Banda N, Van Der Veer C, Mndolo KS, Mponda K, Rylance J, Phiri C, Mallewa J, Nyirenda M, Katha G, Kambiya P, Jafali J, Mwandumba HC, Gordon SB, Cornick J, Jambo KC |
medRxiv : the preprint server for health sciences | 2021 |
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TREATMENT WITH SOLUBLE CD24 ATTENUATES COVID-19-ASSOCIATED SYSTEMIC IMMUNOPATHOLOGY
Song NJ, Allen C, Vilgelm AE, Riesenberg BP, Weller KP, Reynolds K, Chakravarthy KB, Kumar A, Khatiwada A, Sun Z, Ma A, Chang Y, Yusuf M, Li A, Zeng C, Evans JP, Bucci D, Gunasena M, Xu M, Liyanage NP, Bolyard C, Velegraki M, Liu SL, Ma Q, Devenport M, Liu Y, Zheng P, Malvestutto CD, Chung D, Li Z |
2021 | |
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Vandetanib Reduces Inflammatory Cytokines and Ameliorates COVID-19 in Infected Mice.
Puhl AC, Gomes GF, Damasceno S, Fritch EJ, Levi JA, Johnson NJ, Scholle F, Premkumar L, Hurst BL, LeeMontiel F, Veras FP, Batah SS, Fabro AT, Moorman NJ, Yount BL, Dickmander R, Baric R, Pearce KH, Cunha FQ, Alves-Filho JC, Cunha TM, Ekins S |
bioRxiv : the preprint server for biology | 2021 |
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Immuno-fibrotic drivers of impaired lung function in post-acute sequelae of SARS-CoV-2 infection (PASC)
Chun HJ, Coutavas E, Pine A, Lee AI, Yu V, Shallow M, Giovacchini CX, Mathews A, Stephenson B, Que LG, Lee PJ, Kraft BD |
2021 |
