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Abstract
BACKGROUND Elevated levels of inflammatory cytokines have been associated with poor outcomes among COVID-19 patients. It is unknown, however, how these levels compare with those observed in critically ill patients with acute respiratory distress syndrome (ARDS) or sepsis due to other causes.METHODS We used a Luminex assay to determine expression of 76 cytokines from plasma of hospitalized COVID-19 patients and banked plasma samples from ARDS and sepsis patients. Our analysis focused on detecting statistical differences in levels of 6 cytokines associated with cytokine storm (IL-1β, IL-1RA, IL-6, IL-8, IL-18, and TNF-α) between patients with moderate COVID-19, severe COVID-19, and ARDS or sepsis.RESULTS Fifteen hospitalized COVID-19 patients, 9 of whom were critically ill, were compared with critically ill patients with ARDS (n = 12) or sepsis (n = 16). There were no statistically significant differences in baseline levels of IL-1β, IL-1RA, IL-6, IL-8, IL-18, and TNF-α between patients with COVID-19 and critically ill controls with ARDS or sepsis.CONCLUSION Levels of inflammatory cytokines were not higher in severe COVID-19 patients than in moderate COVID-19 or critically ill patients with ARDS or sepsis in this small cohort. Broad use of immunosuppressive therapies in ARDS has failed in numerous Phase 3 studies; use of these therapies in unselected patients with COVID-19 may be unwarranted.FUNDING Funding was received from NHLBI K23 HL125663 (AJR); The Bill and Melinda Gates Foundation OPP1113682 (AJR and CAB); Burroughs Wellcome Fund Investigators in the Pathogenesis of Infectious Diseases #1016687 NIH/NIAID U19AI057229-16; Stanford Maternal Child Health Research Institute; and Chan Zuckerberg Biohub (CAB).
Authors
Jennifer G. Wilson, Laura J. Simpson, Anne-Maud Ferreira, Arjun Rustagi, Jonasel Roque, Adijat Asuni, Thanmayi Ranganath, Philip M. Grant, Aruna Subramanian, Yael Rosenberg-Hasson, Holden T. Maecker, Susan P. Holmes, Joseph E. Levitt, Catherine A. Blish, Angela J. Rogers
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AJP Lung Cellular and Molecular Physiology | 2022 |
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Nervous system manifestations related to COVID-19 and their possible mechanisms
Xie Z, Hui H, Zhao Z, Yu W, Wu R, Zhu Y, Song Y, Cao B, Shi W, Zhao D, Zhao Y, Lv J, Yao Q, Duan Y, Li J, Zhang H, Zhou L, Wang X, Tian Y, Zhao G |
Brain Research Bulletin | 2022 |
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The complex lipid, SPPCT-800, reduces lung damage, improves pulmonary function and decreases pro-inflammatory cytokines in the murine LPS-induced acute respiratory distress syndrome (ARDS) model
Sordillo PP, Allaire A, Bouchard A, Salvail D, Labbe SM |
Pharmaceutical Biology | 2022 |
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Cyanidin-3-O-glucoside and Peonidin-3-O-glucoside-Rich Fraction of Black Rice Germ and Bran Suppresses Inflammatory Responses from SARS-CoV-2 Spike Glycoprotein S1-Induction In Vitro in A549 Lung Cells and THP-1 Macrophages via Inhibition of the NLRP3 Inflammasome Pathway
Semmarath W, Mapoung S, Umsumarng S, Arjsri P, Srisawad K, Thippraphan P, Yodkeeree S, Dejkriengkraikul P |
Nutrients | 2022 |
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Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients
Burnett CE, Okholm TL, Tenvooren I, Marquez DM, Tamaki S, Munoz Sandoval P, Willmore A, Hendrickson CM, Kangelaris KN, Langelier CR, Krummel MF, Woodruff PG, Calfee CS, Erle DJ, Ansel KM, Spitzer MH |
Immunity | 2022 |
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Effect of Urinary Trypsin Inhibitor (Ulinastatin) Therapy in COVID-19
Jain A, Kasliwal R, Jain SS, Jain R, Gupta D, Gupta P, Jain A, Tambi R, Panwar P, Meena M, Jain R |
Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine | 2022 |
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Interleukin-18 Binding Protein in Immune Regulation and Autoimmune Diseases
Park SY, Hisham Y, Shin HM, Yeom SC, Kim S |
Biomedicines | 2022 |
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Immunophenotyping of lymphocytes and monocytes and the status of cytokines in the clinical course of Covid‐19 patients
Idiz UO, Yurttas TT, Degirmencioglu S, Orhan B, Erdogan E, Sevik H, Sevinc MM |
Journal of Medical Virology | 2022 |
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Intranasal Xylitol for the Treatment of COVID-19 in the Outpatient Setting: A Pilot Study.
Soler E, de Mendoza A, Cuello VI, Silva-Vetri MG, Núñez ZH, Ortega RG, Rizvi SA, Sanchez-Gonzalez M, Ferrer G |
Cureus | 2022 |
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A novel logical model of COVID-19 intracellular infection to support therapies development.
Piretto E, Selvaggio G, Bragantini D, Domenici E, Marchetti L |
PLoS computational biology | 2022 |
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SARS-CoV-2 pneumonia and bacterial pneumonia patients differ in a second hit immune response model.
Moser D, Feuerecker M, Biere K, Han B, Hoerl M, Schelling G, Kaufmann I, Choukér A, Woehrle T |
Scientific Reports | 2022 |
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The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals.
Butler-Laporte G, Gonzalez-Kozlova E, Su CY, Zhou S, Nakanishi T, Brunet-Ratnasingham E, Morrison D, Laurent L, Afilalo J, Afilalo M, Henry D, Chen Y, Carrasco-Zanini J, Farjoun Y, Pietzner M, Kimchi N, Afrasiabi Z, Rezk N, Bouab M, Petitjean L, Guzman C, Xue X, Tselios C, Vulesevic B, Adeleye O, Abdullah T, Almamlouk N, Moussa Y, DeLuca C, Duggan N, Schurr E, Brassard N, Durand M, Del Valle DM, Thompson R, Cedillo MA, Schadt E, Nie K, Simons NW, Mouskas K, Zaki N, Patel M, Xie H, Harris J, Marvin R, Cheng E, Tuballes K, Argueta K, Scott I, Greenwood CMT, Paterson C, Hinterberg M, Langenberg C, Forgetta V, Mooser V, Marron T, Beckmann N, Kenigsberg E, Charney AW, Kim-Schulze S, Merad M, Kaufmann DE, Gnjatic S, Richards JB |
Clinical Proteomics | 2022 |
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Bioinformatics and systems biology approach to identify the pathogenetic link of Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Lv Y, Zhang T, Cai J, Huang C, Zhan S, Liu J |
Frontiers in immunology | 2022 |
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Therapeutic plasma exchange: A potential therapeutic modality for critically ill adults with severe acute respiratory syndrome coronavirus 2 infection
Al\u2010Hashami S, Khamis F, Al\u2010Yahyay M, Al\u2010Dowaiki S, Al\u2010Mashaykhi L, Al\u2010Khalili H, Chandwani J, Al\u2010Salmi I, Al\u2010Zakwani I |
Journal of Clinical Apheresis | 2022 |
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Distinct Immune Phenotypes and Cytokine Profiles in Children with Differing Severity of COVID-19
Talarico LB, Toledano A, Contrini MM, Torrado LE, Martínez MP, Gaillard MI, Caratozzolo A, Byrne AB, Bonnin FA, Tineo MS, Yfran EW, Acosta PL, López EL |
The Pediatric Infectious Disease Journal | 2022 |
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Therapeutic advances in COVID-19
Murakami N, Hayden R, Hills T, Al-Samkari H, Casey J, Del Sorbo L, Lawler PR, Sise ME, Leaf DE |
Nature reviews. Nephrology | 2022 |
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Effects of Purinergic Receptor Deletion or Pharmacologic Modulation on Pulmonary Inflammation in Mice
Whitehead GS, Karcz TP, Tosh DK, Jung YH, Wen Z, Campbell RG, Gopinatth V, Gao ZG, Jacobson KA, Cook DN |
2022 | |
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Inflammatory profile of convalescent plasma to treat COVID: Impact of amotosalen/UVA pathogen reduction technology
Cognasse F, Hamzeh-Cognasse H, Duchez AC, Shurko N, Eyraud MA, Arthaud CA, Prier A, Heestermans M, Hequet O, Bonneaudeau B, Rochette-Eribon S, Teyssier F, Barlet-Excoffier V, Chavarin P, Legrand D, Richard P, Morel P, Mooney N, Tiberghien P |
Frontiers in immunology | 2022 |
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COVID-19 Acute Respiratory Distress Syndrome: One Pathogen, Multiple Phenotypes
Empson S, Rogers AJ, Wilson JG |
Critical Care Clinics | 2022 |
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Acteoside attenuates acute lung injury following administration of cobra venom factor to mice
Guo J, Liu QZ, Zhu FJ, Li M, Li J, Guo L, Sun QY, Yang QX |
Heliyon | 2022 |
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SARS-CoV-2 Infection Prompts IL-1β-Mediated Inflammation and Reduces IFN-λ Expression in Human Lung Tissue.
Vezzani B, Neri M, D'Errico S, Papi A, Contoli M, Giorgi C |
2022 | |
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COVID‐19 plasma proteome reveals novel temporal and cell‐specific signatures for disease severity and high‐precision disease management
Iosef C, Martin CM, Slessarev M, Gillio\u2010Meina C, Cepinskas G, Han VK, Fraser DD |
Journal of Cellular and Molecular Medicine | 2022 |
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Determinants of long COVID among adults hospitalized for SARS-CoV-2 infection: A prospective cohort study
Bellan M, Apostolo D, Albè A, Crevola M, Errica N, Ratano G, Tonello S, Minisini R, D\u2019Onghia D, Baricich A, Patrucco F, Zeppegno P, Gramaglia C, Balbo PE, Cappellano G, Casella S, Chiocchetti A, Clivati E, Giordano M, Manfredi M, Patti G, Pinato DJ, Puricelli C, Raineri D, Rolla R, Sainaghi PP, Pirisi M |
Frontiers in immunology | 2022 |
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Biochemical, Biophysical, and Immunological Characterization of Respiratory Secretions in Severe SARS-CoV-2 (COVID-19) Infections.
Kratochvil MJ, Kaber G, Demirdjian S, Cai PC, Burgener EB, Nagy N, Barlow GL, Popescu M, Nicolls MR, Ozawa MG, Regula DP, Pacheco-Navarro AE, Yang S, de Jesus Perez VA, Karmouty-Quintana H, Peters AM, Zhao B, Buja ML, Johnson PY, Vernon RB, Wight TN, Milla CE, Rogers AJ, Spakowitz AJ, Heilshorn SC, Bollyky PL |
medRxiv : the preprint server for health sciences | 2022 |
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Decreased cardiovascular risk factors and inflammation with remission of type 2 diabetes in adults with obesity using a high protein diet: Randomized control trial
Stentz FB, Lawson D, Tucker S, Christman J, Sands C |
2022 | |
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An immune-based biomarker signature is associated with mortality in COVID-19 patients
Michael S. Abers, Ottavia M. Delmonte, Emily E. Ricotta, Jonathan Fintzi, Danielle Fink, Adriana A. de Jesus, Kol A. Zarember, Sara Alehashemi, Vasileios Oikonomou, Jigar V. Desai, Scott W. Canna, Bita Shakoory, Kerry Dobbs, Luisa Imberti, Alessandra Sottini, Eugenia Quiros-Roldan, Francesco Castelli, Camillo Rossi, Duilio Brugnoni, Andrea Biondi, Laura R. Bettini, Mariella D’Angio’, Paolo Bonfanti, Riccardo Castagnoli, Daniela Montagna, Amelia Licari, Gian Luigi Marseglia, Emily Gliniewicz, Elana R. Shaw, Dana Kahle, Andre T. Rastegar, Michael A Stack, Katherine Myint-Hpu, Susan L. Levinson, Mark J. DiNubile, Daniel W. Chertow, Peter Burbelo, Jeffrey I. Cohen, Katherine R. Calvo, John S. Tsang, Helen C. Su, John I. Gallin, Douglas B. Kuhns, Raphaela Goldbach-Mansky, Michail S Lionakis, Luigi D Notarangelo |
JCI Insight | 2021 |
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Carboxypeptidase B blocks ex vivo activation of the anaphylatoxin-neutrophil extracellular trap axis in neutrophils from COVID-19 patients
Y Zhang, K Han, C Du, R Li, J Liu, H Zeng, L Zhu, A Li |
Critical Care | 2021 |
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NK Cell–Derived IL-10 Supports Host Survival during Sepsis
IJ Jensen, PW McGonagill, NS Butler, JT Harty, TS Griffith, VP Badovinac |
Journal of immunology (Baltimore, Md. : 1950) | 2021 |
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RGD‐binding integrins and TGF‐β in SARS‐CoV‐2 infections – novel targets to treat COVID‐19 patients?
I Carvacho, M Piesche |
IBMS BoneKEy | 2021 |
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Problems of Pathogenesis and Pathogenetic Therapy of COVID-19 from the Perspective of the General Theory of Pathological Systems (General Pathological Processes)
E Gusev, A Sarapultsev, D Hu, V Chereshnev |
International journal of molecular sciences | 2021 |
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Neutrophils at the crossroads of acute viral infections and severity
S Rawat, S Vrati, A Banerjee |
Molecular Aspects of Medicine | 2021 |
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Interleukin-6: obstacles to targeting a complex cytokine in critical illness
OJ McElvaney, GF Curley, S Rose-John, NG McElvaney |
The lancet. Respiratory medicine | 2021 |
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Pulmonary fibrosis from molecular mechanisms to therapeutic interventions: lessons from post-COVID-19 patients
C Giacomelli, R Piccarducci, L Marchetti, C Romei, C Martini |
Biochemical Pharmacology | 2021 |
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Covid‐19 and Liver Injury: Role of Inflammatory Endotheliopathy, Platelet Dysfunction, and Thrombosis
MJ McConnell, R Kondo, N Kawaguchi, Y Iwakiri |
Hepatology Communications | 2021 |
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Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19
AJ Wilk, MJ Lee, B Wei, B Parks, R Pi, GJ Martínez-Colón, T Ranganath, NQ Zhao, S Taylor, W Becker, T Ranganath, NQ Zhao, AJ Wilk, R Vergara, JL McKechnie, L de la Parte, KW Dantzler, M Ty, N Kathale, GJ Martinez-Colon, A Rustagi, G Ivison, R Pi, MJ Lee, R Brewer, T Hollis, A Baird, M Ugur, M Tal, D Bogusch, G Nahass, K Haider, KQ Tran, L Simpson, H Din, J Roque, R Mann, I Chang, E Do, A Fernandes, SC Lyu, W Zhang, M Manohar, J Krempski, A Visweswaran, EJ Zudock, K Jee, K Kumar, JA Newberry, JV Quinn, D Schreiber, EA Ashley, CA Blish, AL Blomkalns, KC Nadeau, R OHara, AJ Rogers, S Yang, D Jimenez-Morales, AL Blomkalns, R OHara, EA Ashley, KC Nadeau, S Yang, S Holmes, M Rabinovitch, AJ Rogers, WJ Greenleaf, CA Blish |
Journal of Experimental Medicine | 2021 |
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Transcriptomic similarities and differences in host response between SARS-CoV-2 and other viral infections
SA Thair, YD He, Y Hasin-Brumshtein, S Sakaram, R Pandya, J Toh, D Rawling, M Remmel, S Coyle, GN Dalekos, I Koutsodimitropoulos, G Vlachogianni, E Gkeka, E Karakike, G Damoraki, N Antonakos, P Khatri, EJ Giamarellos-Bourboulis, TE Sweeney |
iScience | 2021 |
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Neurobiology of SARS-CoV-2 interactions with the peripheral nervous system: implications for COVID-19 and pain
AJ McFarland, MS Yousuf, S Shiers, TJ Price |
PAIN Reports | 2021 |
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The Role of Innate Immunity and Bioactive Lipid Mediators in COVID-19 and Influenza
S Sahanic, J Löffler-Ragg, P Tymoszuk, R Hilbe, E Demetz, RK Masanetz, M Theurl, J Holfeld, C Gollmann-Tepeköylü, A Tzankov, G Weiss, M Giera, I Tancevski |
Frontiers in physiology | 2021 |
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The Association of COVID-19 With Acute Kidney Injury Independent of Severity of Illness: A Multicenter Cohort Study
DG Moledina, M Simonov, Y Yamamoto, J Alausa, T Arora, A Biswas, LG Cantley, L Ghazi, JH Greenberg, M Hinchcliff, C Huang, SG Mansour, M Martin, A Peixoto, W Schulz, L Subair, JM Testani, U Ugwuowo, P Young, FP Wilson |
American journal of kidney diseases : the official journal of the National Kidney Foundation | 2021 |
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The potential of COVID-19 patients’ sera to cause antibody-dependent enhancement of infection and IL-6 production
J Shimizu, T Sasaki, A Yamanaka, Y Ichihara, R Koketsu, Y Samune, P Cruz, K Sato, N Tanga, Y Yoshimura, A Murakami, M Yamada, K Itoi, EE Nakayama, K Miyazaki, T Shioda |
Scientific Reports | 2021 |
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Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS
A Sarma, SA Christenson, A Byrne, E Mick, AO Pisco, C DeVoe, T Deiss, R Ghale, BS Zha, A Tsitsiklis, A Jauregui, F Moazed, AM Detweiler, N Spottiswoode, P Sinha, N Neff, M Tan, PH Serpa, A Willmore, KM Ansel, JG Wilson, A Leligdowicz, ER Siegel, M Sirota, JL DeRisi, MA Matthay, Y Abe-Jones, S Asthana, A Beagle, T Bhakta, S Bhide, C Cai, S Caldera, C Calfee, M Calvo, S Carrillo, A Cattamanchi, S Chak, V Chan, N Chew, S Christenson, Z Collins, A Combes, T Courau, S Darmanis, D Erle, A Esmaili, GK Fragiadakis, R Ghale, J Giberson, A Gonzalez, PH Serpa, C Hendrickson, K Hiam, K Hu, B Huang, A Jauregui, C Jones, N Jones, K Kangelaris, M Krummel, N Kumar, D Kushnoor, T Lea, D Lee, D Lee, KD Liu, Y Liu, S Mahboob, M Matthay, J Milush, P Muñoz-Sandoval, V Nguyen, G Ortiz, R Parada, M Phelps, L Pierce, P Prasad, A Rao, S Rashid, G Reeder, N Rodriguez, B Samad, D Scarlet, C Shaw, A Shen, A Sigman, M Spitzer, Y Sun, S Sunshine, K Tang, LT Altamirano, J Tsui, E Tumurbaatar, K Turner, A Ward, A Willmore, M Wilson, J Winkler, R Withers, K Wong, P Woodruff, J Ye, K Yee, M Yu, S Zha, J Zhan, M Zhou, WS Zhu, CM Hendrickson, KN Kangelaris, MF Krummel, PG Woodruff, DJ Erle, CS Calfee, CR Langelier |
Nature Communications | 2021 |
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COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone
Aartik Sarma, Stephanie Christenson, Eran Mick, Thomas Deiss, Catherine DeVoe, Angela Pisco, Rajani Ghale, Alejandra Jauregui, Ashley Byrne, Farzad Moazed, Natasha Spottiswoode, Pratik Sinha, Beth Zha, Norma Neff, Michelle Tan, Paula Hayakawa Serpa, K Mark Ansel, Jennifer Wilson, Aleksandra Leligdowicz, Emily Seigel, Marina Sirota, Joseph DeRisi, Michael Matthay, Comet Consortium, Carolyn Hendrickson, Kirsten Kangelaris, Matthew Krummel, Prescott Woodruff, David Erle, Carolyn Calfee, Charles Langelier |
Research square | 2021 |
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Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions
MR Filbin, A Mehta, AM Schneider, KR Kays, JR Guess, M Gentili, BG Fenyves, NC Charland, AL Gonye, I Gushterova, HK Khanna, TJ LaSalle, KM Lavin-Parsons, BM Lilley, CL Lodenstein, K Manakongtreecheep, JD Margolin, BN McKaig, M Rojas-Lopez, BC Russo, N Sharma, J Tantivit, MF Thomas, RE Gerszten, GS Heimberg, PJ Hoover, DJ Lieb, B Lin, D Ngo, K Pelka, M Reyes, CS Smillie, A Waghray, TE Wood, AS Zajac, LL Jennings, I Grundberg, RP Bhattacharyya, BA Parry, AC Villani, M Sade-Feldman, N Hacohen, MB Goldberg |
Cell reports. Medicine | 2021 |
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Hallmarks of immune response in COVID-19: Exploring dysregulation and exhaustion
A Mazzoni, L Salvati, L Maggi, F Annunziato, L Cosmi |
Seminars in Immunology | 2021 |
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High Levels of Circulating IL-8 and Soluble IL-2R Are Associated With Prolonged Illness in Patients With Severe COVID-19
A Ma, L Zhang, X Ye, J Chen, J Yu, L Zhuang, C Weng, F Petersen, Z Wang, X Yu |
Frontiers in immunology | 2021 |
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Immune profiling of COVID-19: preliminary findings and implications for the pandemic
HT Maecker |
Journal for ImmunoTherapy of Cancer | 2021 |
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Pathophysiology of acute respiratory syndrome coronavirus 2 infection: a systematic literature review to inform EULAR points to consider
A Najm, A Alunno, X Mariette, B Terrier, GD Marco, J Emmel, L Mason, DG McGonagle, PM Machado |
RMD Open | 2021 |
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Severe Acute Respiratory Syndrome Coronavirus 2: Manifestations of Disease and Approaches to Treatment and Prevention in Humans
ME Watson, K Inagaki, JB Weinberg |
Comparative medicine | 2021 |
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Convalescent COVID-19 Patients Without Comorbidities Display Similar Immunophenotypes Over Time Despite Divergent Disease Severities
CF Chu, F Sabath, S Fibi-Smetana, S Sun, R Öllinger, E Noeßner, YY Chao, L Rinke, E Winheim, R Rad, AB Krug, L Taher, CE Zielinski |
Frontiers in immunology | 2021 |
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Unique inflammatory profile is associated with higher SARS-CoV-2 acute respiratory distress syndrome (ARDS) mortality
J Balnis, AP Adam, A Chopra, HC Chieng, LA Drake, N Martino, RB Ramos, PJ Feustel, KA Overmyer, E Shishkova, JJ Coon, HA Singer, MA Judson, A Jaitovich |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2021 |
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Immunometabolic signatures predict risk of progression to sepsis in COVID-19
AS Oostdam, JE Castañeda-Delgado, JJ Oropeza-Valdez, JC Borrego, J Monárrez-Espino, J Zheng, R Mandal, L Zhang, E Soto-Guzmán, JC Fernández-Ruiz, F Ochoa-González, FM Medinilla, JA López, DS Wishart, JA Enciso-Moreno, Y López-Hernández, C Lazzeri |
PloS one | 2021 |
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Parallels in Sepsis and COVID-19 Conditions: Implications for Managing Severe COVID-19
CO Olwal, NN Nganyewo, K Tapela, AL Zune, O Owoicho, Y Bediako, S Duodu |
Frontiers in immunology | 2021 |
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SARS-CoV-2 Infection Modulates ACE2 Function and Subsequent Inflammatory Responses in Swabs and Plasma of COVID-19 Patients
L Gutiérrez-Chamorro, E Riveira-Muñoz, C Barrios, V Palau, M Nevot, S Pedreño-López, J Senserrich, M Massanella, B Clotet, C Cabrera, O Mitjà, M Crespo, J Pascual, M Riera, E Ballana |
Viruses | 2021 |
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Nucleocapsid and Spike Proteins of the Coronavirus SARS-CoV-2 Induce IL6 in Monocytes and Macrophages—Potential Implications for Cytokine Storm Syndrome
I Karwaciak, A Sałkowska, K Karaś, J Dastych, M Ratajewski |
Human vaccines | 2021 |
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Integrated immune dynamics define correlates of COVID-19 severity and antibody responses
M Koutsakos, LC Rowntree, L Hensen, BY Chua, CE van de Sandt, JR Habel, W Zhang, X Jia, L Kedzierski, TM Ashhurst, GH Putri, F Marsh-Wakefield, MN Read, DN Edwards, EB Clemens, CY Wong, FL Mordant, JA Juno, F Amanat, J Audsley, NE Holmes, CL Gordon, OC Smibert, JA Trubiano, CM Hughes, M Catton, JT Denholm, SY Tong, DL Doolan, TC Kotsimbos, DC Jackson, F Krammer, DI Godfrey, AW Chung, NJ King, SR Lewin, AK Wheatley, SJ Kent, K Subbarao, J McMahon, I Thevarajan, TH Nguyen, AC Cheng, K Kedzierska |
Cell reports. Medicine | 2021 |
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Severe COVID-19 Patients Show an Increase in Soluble TNFR1 and ADAM17, with a Relationship to Mortality
Y Palacios, A Ruiz, LA Ramón-Luing, R Ocaña-Guzman, O Barreto-Rodriguez, A Sánchez-Monciváis, B Tecuatzi-Cadena, AG Regalado-García, RD Pineda-Gudiño, A García-Martínez, F Juárez-Hernández, JP Farias-Contreras, I Fricke-Galindo, G Pérez-Rubio, R Falfán-Valencia, I Buendia-Roldan, K Medina-Quero, L Chavez-Galan |
International journal of molecular sciences | 2021 |
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Cytokine storms, evolution and COVID-19
J Alcock, A Masters |
Evolution, Medicine, and Public Health | 2021 |
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Reference Gene Selection for Gene Expression Analyses in Mouse Models of Acute Lung Injury
A Fragoulis, K Biller, S Fragoulis, D Lex, S Uhlig, LK Reiss |
International journal of molecular sciences | 2021 |
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Hide and seek in a pandemic: review of SARS‐CoV‐2 infection and sequelae in children
JA Clark, N Pathan |
Experimental Physiology | 2021 |
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Dissecting the common and compartment-specific features of COVID-19 severity in the lung and periphery with single-cell resolution
KJ Overholt, JR Krog, I Zanoni, BD Bryson |
iScience | 2021 |
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Corticosteroid therapy for 2019‐nCoV‐infected patients: A case series of eight mechanically ventilated patients
M ALRasheedi, Y Alhazmi, N Almaqwashi, AM Ali, A Kardam, M Sharaf, KH Haider |
Clinical Case Reports | 2021 |
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Bergenin Monohydrate Attenuates Inflammatory Response via MAPK and NF-κB Pathways Against Klebsiella pneumonia Infection
Q Tang, Q Wang, Z Sun, S Kang, Y Fan, Z Hao |
Frontiers in pharmacology | 2021 |
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The intersection of COVID-19 and autoimmunity: What is our current understanding?
NE Winchester, C Calabrese, L Calabrese |
Pathogens and Immunity | 2021 |
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Identifying clinical and biochemical phenotypes in acute respiratory distress syndrome secondary to coronavirus disease-2019
S Ranjeva, R Pinciroli, E Hodell, A Mueller, CC Hardin, BT Thompson, L Berra |
2021 | |
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Is IL-6 a key cytokine target for therapy in COVID-19?
SA Jones, CA Hunter |
Nature Reviews Immunology | 2021 |
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A Pictorial Review of the Role of Imaging in the Detection, Management, Histopathological Correlations, and Complications of COVID-19 Pneumonia
B Brogna, E Bignardi, C Brogna, M Volpe, G Lombardi, A Rosa, G Gagliardi, PF Capasso, E Gravino, F Maio, F Pane, V Picariello, M Buono, L Colucci, LA Musto |
Diagnostics | 2021 |
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Clinical significance of measuring serum cytokine levels as inflammatory biomarkers in adult and pediatric COVID-19 cases: A review
BM Liu, TB Martins, LK Peterson, HR Hill |
Cytokine | 2021 |
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Selection of the Appropriate Control Group Is Essential in Evaluating the Cytokine Storm in COVID-19
AG Vassiliou, I Dimopoulou, E Jahaj, C Keskinidou, Z Mastora, SE Orfanos, A Kotanidou |
In vivo (Athens, Greece) | 2021 |
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COVID-19 versus Non–COVID-19 Acute Respiratory Distress Syndrome: Comparison of Demographics, Physiologic Parameters, Inflammatory Biomarkers, and Clinical Outcomes
W Bain, H Yang, FA Shah, T Suber, C Drohan, N Al-Yousif, RS DeSensi, N Bensen, C Schaefer, BR Rosborough, A Somasundaram, CJ Workman, C Lampenfeld, AR Cillo, C Cardello, F Shan, TC Bruno, DA Vignali, P Ray, A Ray, Y Zhang, JS Lee, B Methé, BJ McVerry, A Morris, GD Kitsios |
Annals of the American Thoracic Society | 2021 |
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COVID-19 Coagulopathy: Current knowledge and guidelines on anticoagulation
JK Salabei, TJ Fishman, ZT Asnake, A Ali, UG Iyer |
Heart & lung : the journal of critical care | 2021 |
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Molecular Hydrogen: A Promising Adjunctive Strategy for the Treatment of the COVID-19
Y Li, Z Wang, N Lian, Y Wang, W Zheng, K Xie |
Frontiers in Medicine | 2021 |
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Serial measurement of cytokines strongly predict COVID-19 outcome
HS Ozger, R Karakus, EN Kuscu, UE Bagriacik, N Oruklu, M Yaman, M Turkoglu, G Erbas, AY Atak, E Senol, E Ito |
PloS one | 2021 |
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Elements of Th1/Th2 response and disease severity in COVID‐19 patients: A short report
K Akinosoglou, AL Delastic, V Dimakopoulou, M Marangos, C Gogos |
Journal of Medical Virology | 2021 |
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Chemokine-Based Therapeutics for the Treatment of Inflammatory and Fibrotic Convergent Pathways in COVID-19
DR Julian, MA Kazakoff, A Patel, J Jaynes, MS Willis, CC Yates |
Current Pathobiology Reports | 2021 |
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Vitamin D Endocrine System and COVID‐19
R Bouillon, JM QuesadaGomez |
JBMR Plus | 2021 |
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Acute Chelation Therapy‐Associated Changes in Urine Gadolinium, Self-reported Flare Severity, and Serum Cytokines in Gadolinium Deposition Disease
HT Maecker, JC Siebert, Y Rosenberg-Hasson, LM Koran, M Ramalho, RC Semelka |
Investigative Radiology | 2021 |
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Impact of obesity on COVID-19 patients
W Yu, KE Rohli, S Yang, P Jia |
Journal of Diabetes and its Complications | 2021 |
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The risk factor for instability metabolic health and severity
DA Al-Koofee, AM Omara, AB Abulrazzaq, R Zaid |
2021 | |
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Differential Cytokine Signatures of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Influenza Infection Highlight Key Differences in Pathobiology
A Karaba, W Zhou, L Hsieh, A Figueroa, G Massaccesi, R Rothman, K Fenstermacher, L Sauer, K Shaw-Saliba, P Blair, M Robinson, S Leung, R Wesson, N Alachkar, R El-Diwany, H Ji, A Cox |
Clinical Infectious Diseases | 2021 |
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Utility of Coronavirus Disease 2019 Immune Profiling for the Clinician at the Bedside*
SJ Minkove, P Torabi-Parizi |
Critical Care Medicine | 2021 |
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Corticosteroids for COVID-19
Annane D |
2021 | |
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COVID-19 and myeloid cells: complex interplay correlates with lung severity
Franco R. D'Alessio, Nicola M. Heller |
Journal of Clinical Investigation | 2020 |
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Flow cytometric evaluation of the neutrophil compartment in COVID‐19 at hospital presentation: A normal response to an abnormal situation
R Spijkerman, SH Bongers, BJ Bindels, GH Tinnevelt, G Giustarini, NK Jorritsma, W Buitenwerf, DE Spengler, EM Delemarre, S Nierkens, HM Goor, JJ Jansen, N Vrisekoop, F Hietbrink, LP Leenen, KA Kaasjager, L Koenderman |
Journal of leukocyte biology | 2020 |
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Flattening the COVID-19 Curve With Natural Killer Cell Based Immunotherapies
M Market, L Angka, AB Martel, D Bastin, O Olanubi, G Tennakoon, DM Boucher, J Ng, M Ardolino, RC Auer |
Frontiers in immunology | 2020 |
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The role of interleukin‐18 in the diagnosis and monitoring of hemophagocytic lymphohistiocytosis/macrophage activation syndrome – a systematic review
JM Krei, HJ Møller, JB Larsen |
Clinical & Experimental Immunology | 2020 |
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Efficacy and safety of early treatment with sarilumab in hospitalised adults with COVID-19 presenting cytokine release syndrome (SARICOR STUDY): protocol of a phase II, open-label, randomised, multicentre, controlled clinical trial
RL López, SC Fernández, LL Pérez, AR Palacios, MC Fernández-Roldán, EA Alonso, IP Camacho, J Rodriguez-Baño, N Merchante, J Olalla, MÁ Esteban-Moreno, M Santos, A Luque-Pineda, J Torre-Cisneros |
BMJ Open | 2020 |
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Pulmonary vascular improvement in severe COVID-19 patients treated with tocilizumab
L Salvati, M Occhipinti, L Gori, L Ciani, A Mazzoni, L Maggi, M Capone, P Parronchi, F Liotta, V Miele, F Annunziato, F Lavorini, L Cosmi |
Immunology Letters | 2020 |
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A High-Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury
M Kost-Alimova, EH Sidhom, A Satyam, BT Chamberlain, M Dvela-Levitt, M Melanson, SL Alper, J Santos, J Gutierrez, A Subramanian, PJ Byrne, E Grinkevich, E Reyes-Bricio, C Kim, AR Clark, AJ Watts, R Thompson, J Marshall, JL Pablo, J Coraor, J Roignot, KA Vernon, K Keller, A Campbell, M Emani, M Racette, S Bazua-Valenti, V Padovano, A Weins, SP McAdoo, FW Tam, L Ronco, F Wagner, GC Tsokos, JL Shaw, A Greka |
Reproduction | 2020 |
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SOCS, Intrinsic Virulence Factors, and Treatment of COVID-19
HM Johnson, AS Lewin, CM Ahmed |
Frontiers in immunology | 2020 |
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SARS‐CoV‐2 infection, COVID‐19 pathogenesis, and exposure to air pollution: What is the connection?
B Woodby, MM Arnold, G Valacchi |
Annals of the New York Academy of Sciences | 2020 |
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Biomimetic Nanoparticles Potentiate the Anti-Inflammatory Properties of Dexamethasone and Reduce the Cytokine Storm Syndrome: An Additional Weapon against COVID-19?
R Molinaro, A Pasto, F Taraballi, F Giordano, JA Azzi, E Tasciotti, C Corbo |
Nanomaterials | 2020 |
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A score combining early detection of cytokines accurately predicts COVID-19 severity and intensive care unit transfer
C Nagant, F Ponthieux, J Smet, N Dauby, V Doyen, T Besse-Hammer, DD Bels, E Maillart, F Corazza |
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases | 2020 |
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Delving beneath the surface of hyperinflammation in COVID-19
K Reddy, AJ Rogers, DF McAuley |
2020 | |
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Mortality in COVID-19 patients with acute respiratory distress syndrome and corticosteroids use: a systematic review and meta-analysis
SS Hasan, T Capstick, R Ahmed, CS Kow, F Mazhar, H a Merchant, ST Zaidi |
Expert Review of Respiratory Medicine | 2020 |
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Unique inflammatory profile is associated with higher SARS-CoV-2 acute respiratory distress syndrome (ARDS) mortality.
Balnis J, Adam AP, Chopra A, Chieng HC, Drake LA, Martino N, Ramos RB, Feustel PJ, Overmyer KA, Shishkova E, Coon JJ, Singer HA, Judson MA, Jaitovich A |
2020 | |
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A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic
Alimova M, Sidhom EH, Satyam A, Dvela-Levitt M, Melanson M, Chamberlain BT, Alper SL, Santos J, Gutierrez J, Subramanian A, Grinkevich E, Bricio ER, Kim C, Clark A, Watts A, Thompson R, Marshall J, Pablo JL, Coraor J, Roignot J, Vernon KA, Keller K, Campbell A, Emani M, Racette M, Bazua-Valenti S, Padovano V, Weins A, McAdoo SP, Tam FW, Ronco L, Wagner F, Tsokos GC, Shaw JL, Greka A |
2020 | |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
