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Potential role of intermittent functioning of baroreflexes in the etiology of hypertension in spontaneously hypertensive rats
Feng Gu, … , Daniel E. Michele, Daniel A. Beard
Feng Gu, … , Daniel E. Michele, Daniel A. Beard
Published October 2, 2020
Citation Information: JCI Insight. 2020;5(19):e139789. https://doi.org/10.1172/jci.insight.139789.
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Research Article Cardiology

Potential role of intermittent functioning of baroreflexes in the etiology of hypertension in spontaneously hypertensive rats

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Abstract

The spontaneously hypertensive rat (SHR) is a genetic model of primary hypertension with an etiology that includes sympathetic overdrive. To elucidate the neurogenic mechanisms underlying the pathophysiology of this model, we analyzed the dynamic baroreflex response to spontaneous fluctuations in arterial pressure in conscious SHRs, as well as in the Wistar-Kyoto (WKY), the Dahl salt-sensitive, the Dahl salt-resistant, and the Sprague-Dawley rat. Observations revealed the existence of long intermittent periods (lasting up to several minutes) of engagement and disengagement of baroreflex control of heart rate. Analysis of these intermittent periods revealed a predictive relationship between increased mean arterial pressure and progressive baroreflex disengagement that was present in the SHR and WKY strains but absent in others. This relationship yielded the hypothesis that a lower proportion of engagement versus disengagement of the baroreflex in SHR compared with WKY contributes to the hypertension (or increased blood pressure) in SHR compared with WKY. Results of experiments using sinoaortic baroreceptor denervation were consistent with the hypothesis that dysfunction of the baroreflex contributes to the etiology of hypertension in the SHR. Thus, this study provides experimental evidence for the roles of the baroreflex in long-term arterial pressure regulation and in the etiology of primary hypertension in this animal model.

Authors

Feng Gu, E. Benjamin Randall, Steven Whitesall, Kimber Converso-Baran, Brian E. Carlson, Gregory D. Fink, Daniel E. Michele, Daniel A. Beard

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Figure 2

Identification of baroreflex on and off states.

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Identification of baroreflex on and off states.
(A) Direct conscious art...
(A) Direct conscious arterial BP measurement taken at 9:30 p.m. to 9:35 p.m. and 4:25 a.m. to 4:30 a.m. from a 15-week-old male SHR (SHRM6). (B) Corresponding RR interval (RR = 1/HR) measured by the telemetry (RRdata: black lines) versus model prediction (RRmodel: red lines). (C) The change of RR interval per unit time reflected in data (μd) is plotted versus change in RR interval per unit time predicted by the model (μm). Data points located between the boundary curves (green) are classified as corresponding to the on state (white area), while the others are classified as corresponding to an off state (gray area). (D) Observed and model-predicted RR interval are plotted for the two 5-minute time windows with on state (white) and off state (gray). (E) Observed and model-predicted RR interval are plotted for the two 5-minute time windows with times in off state colored gray after filtering to remove noise. (F) Observed and model-predicted RR interval are plotted for the twelve 5-minute time windows recorded over a 12-hour dark cycle with times in off state colored gray for SHRM6 at 15 weeks old. (G) Model predictions (red) are compared with data (black) during on-state times for the twelve 5-minute windows.

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