Overweight and obesity could not predicate all-cause mortality in metabolically healthy individuals

Qiuyue Tian; Anxin Wang; Yingting Zuo; Shuohua Chen; Haifeng Hou; Wei Wang; Shouling Wu; Youxin Wang

doi:10.1172/jci.insight.136982

Overweight and obesity could not predicate all-cause mortality in metabolically healthy individuals

Qiuyue Tian,¹ Anxin Wang,² Yingting Zuo,¹ Shuohua Chen,³ Haifeng Hou,⁴ Wei Wang,⁴ Shouling Wu,³ and Youxin Wang¹

First published July 14, 2020 - More info

BACKGROUND. Metabolically healthy obesity (MHO) and metabolically healthy overweight (MH-OW) have been suggested to be an important and emerging phenotype with an increased risk of cardiovascular disease (CVD). However, whether MHO and MH-OW are associated with all-cause mortality remains inconsistent.

METHODS. The association of MHO and MH-OW and all-cause mortality was determined in China community-based prospective cohort study (Kailuan Study) including 93,272 adults at baseline. Data were analyzed from 2006 to 2017. Participants were categorized into six mutually exclusive groups according to the body mass index (BMI) and metabolic syndrome (MetS) status. The primary outcome is all-cause death, whereas accidental deaths were excluded.

RESULTS. During a median follow-up of 11.04 years (interquartile range: 10.74-11.22 years), 8,977 deaths occurred. Compared to healthy participants with normal BMI (MH-NW), MH-OW had lowest risk of all-cause mortality (multivariate-adjusted hazard ratio [aHR]: 0.926; 95% confidence interval [CI]: 0.861 to 0.997), whereas there was no increased or decreased risk for MHO (aHR: 1.009; 95% CI: 0.886 to 1.148). Stratified analyses and sensitivity analyses further validated that nonsignificant association between MHO and all-cause mortality.

CONCLUSIONS. Overweight and obesity do not predicate increased risk of all-cause mortality in metabolic healthy Chinese individuals.

Overweight and obesity could not predicate all-cause mortality in metabolically healthy individuals

Qiuyue Tian,¹ Anxin Wang,² Yingting Zuo,¹ Shuohua Chen,³ Haifeng Hou,⁴ Wei Wang,⁴ Shouling Wu,³ and Youxin Wang¹

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Overweight and obesity could not predicate all-cause mortality in metabolically healthy individuals

Qiuyue Tian,1 Anxin Wang,2 Yingting Zuo,1 Shuohua Chen,3 Haifeng Hou,4 Wei Wang,4 Shouling Wu,3 and Youxin Wang1

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Qiuyue Tian,¹ Anxin Wang,² Yingting Zuo,¹ Shuohua Chen,³ Haifeng Hou,⁴ Wei Wang,⁴ Shouling Wu,³ and Youxin Wang¹