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Usage Information

B lymphocytes protect islet β cells in diabetes-prone NOD mice treated with imatinib
Christopher S. Wilson, … , Roland W. Stein, Daniel J. Moore
Christopher S. Wilson, … , Roland W. Stein, Daniel J. Moore
Published April 9, 2019
Citation Information: JCI Insight. 2019;4(9):e125317. https://doi.org/10.1172/jci.insight.125317.
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Research Article Metabolism

B lymphocytes protect islet β cells in diabetes-prone NOD mice treated with imatinib

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Abstract

Imatinib (Gleevec) reverses type 1 diabetes (T1D) in NOD mice and is currently in clinical trials in individuals with recent-onset disease. While research has demonstrated that imatinib protects islet β cells from the harmful effects of ER stress, the role the immune system plays in its reversal of T1D has been less well understood, and specific cellular immune targets have not been identified. In this study, we demonstrate that B lymphocytes, an immune subset that normally drives diabetes pathology, are unexpectedly required for reversal of hyperglycemia in NOD mice treated with imatinib. In the presence of B lymphocytes, reversal was linked to an increase in serum insulin concentration, but not an increase in islet β cell mass or proliferation. However, improved β cell function was reflected by a partial recovery of expression of the transcription factor MafA, a sensitive marker of islet β cell stress that is important for adult β cell function. Imatinib treatment was found to increase the antioxidant capacity of B lymphocytes, improving ROS handling in NOD islets. This study reveals a mechanism through which imatinib enables B lymphocytes to orchestrate functional recovery of T1D β cells.

Authors

Christopher S. Wilson, Jason M. Spaeth, Jay Karp, Blair T. Stocks, Emilee M. Hoopes, Roland W. Stein, Daniel J. Moore

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Usage data is cumulative from March 2022 through March 2023.

Usage JCI PMC
Text version 657 133
PDF 92 29
Figure 173 0
Supplemental data 47 2
Citation downloads 30 0
Totals 999 164
Total Views 1,163
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

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