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Usage Information

Emerging functions of DNA transposases and oncogenic mutators in childhood cancer development
Anton G. Henssen, Alex Kentsis
Anton G. Henssen, Alex Kentsis
Published October 18, 2018
Citation Information: JCI Insight. 2018;3(20):e123172. https://doi.org/10.1172/jci.insight.123172.
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Emerging functions of DNA transposases and oncogenic mutators in childhood cancer development

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Abstract

Our understanding of the molecular pathogenesis of childhood cancers has advanced substantially, but their fundamental causes remain poorly understood. Recently, multiple mechanisms of DNA damage and repair have been associated with mutations observed in human cancers. Here, we review the physiologic functions and oncogenic activities of transposable genetic elements. In particular, we focus on the recent studies implicating DNA transposases RAG1/2 and PGBD5 as oncogenic mutators that promote genomic rearrangements in childhood leukemias and solid tumors. We outline future studies that will be needed to define the contributions of transposons to mutational processes that become dysregulated in cancer cells. In addition, we discuss translational approaches, including synthetic lethal strategies, for identifying and developing improved clinical therapies to target oncogenic transposons and transposases.

Authors

Anton G. Henssen, Alex Kentsis

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Usage data is cumulative from August 2021 through August 2022.

Usage JCI PMC
Text version 575 247
PDF 100 28
Figure 79 2
Table 45 0
Citation downloads 22 0
Totals 821 277
Total Views 1,098

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

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