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Citations to this article

Polygenic risk score for predicting weight loss after bariatric surgery
Juan de Toro-Martín, … , Simon Marceau, Marie-Claude Vohl
Juan de Toro-Martín, … , Simon Marceau, Marie-Claude Vohl
Published September 6, 2018
Citation Information: JCI Insight. 2018;3(17):e122011. https://doi.org/10.1172/jci.insight.122011.
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Clinical Research and Public Health Genetics Article has an altmetric score of 7

Polygenic risk score for predicting weight loss after bariatric surgery

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Abstract

BACKGROUND. The extent of weight loss among patients undergoing bariatric surgery is highly variable. Herein, we tested the contribution of genetic background to such interindividual variability after biliopancreatic diversion with duodenal switch. METHODS. Percentage of excess body weight loss (%EBWL) was monitored in 865 patients over a period of 48 months after bariatric surgery, and two polygenic risk scores were constructed with 186 and 11 (PRS186 and PRS11) single nucleotide polymorphisms previously associated with body mass index (BMI). RESULTS. The accuracy of the %EBWL logistic prediction model — including initial BMI, age, sex, and surgery modality, and assessed as the area under the receiver operating characteristics (ROC) curve adjusted for optimism (AUCadj = 0.867) — significantly increased after the inclusion of PRS186 (ΔAUCadj = 0.021; 95% CI of the difference [95% CIdiff] = 0.005–0.038) but not PRS11 (ΔAUCadj= 0.008; 95% CIdiff= –0.003–0.019). The overall fit of the longitudinal linear mixed model for %EBWL showed a significant increase after addition of PRS186 (–2 log-likelihood = 12.3; P = 0.002) and PRS11 (–2 log-likelihood = 9.9; P = 0.007). A significant interaction with postsurgery time was found for PRS186 (β = –0.003; P = 0.008) and PRS11 (β = –0.008; P = 0.03). The inclusion of PRS186 and PRS11 in the model improved the cost-effectiveness of bariatric surgery by reducing the percentage of false negatives from 20.4% to 10.9% and 10.2%, respectively. CONCLUSION. These results revealed that genetic background has a significant impact on weight loss after biliopancreatic diversion with duodenal switch. Likewise, the improvement in weight loss prediction after addition of polygenic risk scores is cost-effective, suggesting that genetic testing could potentially be used in the presurgical assessment of patients with severe obesity. FUNDING. Heart and Stroke Foundation of Canada (G-17-0016627) and Canada Research Chair in Genomics Applied to Nutrition and Metabolic Health (no. 950-231-580).

Authors

Juan de Toro-Martín, Frédéric Guénard, André Tchernof, Louis Pérusse, Simon Marceau, Marie-Claude Vohl

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 Total
Citations: 2 4 2 3 3 5 4 23
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Citations to this article (23)

Title and authors Publication Year
Optimizing Nutritional Management Before and After Bariatric Surgery: A Comprehensive Guide for Sustained Weight Loss and Metabolic Health
Frias-Toral E, Chapela S, Gonzalez V, Martinuzzi A, Locatelli J, Llobera N, Manrique E, Sarno G, Mingo M, Marchese F, Cuomo R, Romaniello L, Perna M, Giordano A, Santella B, Schiavo L
Nutrients 2025
Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery.
German J, Cordioli M, Tozzo V, Urbut S, Arumäe K, Smit RAJ, Lee J, Li JH, Janucik A, Ding Y, Akinkuolie A, Heyne HO, Eoli A, Saad C, Al-Sarraj Y, Abdel-Latif R, Mohammed S, Hail MA, Barry A, Wang Z, Cajuso T, Corbetta A, Natarajan P, Ripatti S, Philippakis A, Szczerbinski L, Pasaniuc B, Kutalik Z, Mbarek H, Loos RJF, Vainik U, Ganna A
Nature medicine 2025
Assessment of the impact of a personalised nutrition intervention in impaired glucose regulation over 26 weeks: a randomised controlled trial
Karvela M, Golden CT, Bell N, Martin-Li S, Bedzo-Nutakor J, Bosnic N, DeBeaudrap P, de Mateo-Lopez S, Alajrami A, Qin Y, Eze M, Hon TK, Simón-Sánchez J, Sahoo R, Pearson-Stuttard J, Soon-Shiong P, Toumazou C, Oliver N
Scientific Reports 2024
Socio-Demographic and Preoperative Clinical Factors Associated With 5-Year Weight Trajectories After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy
Patel S, Jiang C, Cowan B, Yin J, Schaefer C, Dutta S, Mostaedi R, Choquet H
2024
Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery: a multi-ancestry study in 10 960 individuals from 9 biobanks
German J, Cordioli M, Tozzo V, Urbut S, Arumäe K, Smit RA, Lee J, Li JH, Janucik A, Ding Y, Akinkuolie A, Heyne H, Eoli A, Saad C, Al-Sarraj Y, Abdel-latif R, Barry A, Wang Z, Natarajan P, Ripatti S, Philippakis A, Szczerbinski L, Pasaniuc B, Mbarek H, Loos RJ, Vainik U, Ganna A
medRxiv 2024
The melanocortin-4 receptor pathway and the emergence of precision medicine in obesity management
Fansa S, Acosta A
Diabetes, obesity & metabolism 2024
Parental Obesity Predisposition and Age of Onset Associate with Poor Response to Bariatric and Metabolic Surgery
Fink M, Herrmann S, Fink J, Lässle C, Marjanovic G, Fagnocchi L, Pospisilik JA, Fichtner-Feigl S, Seifert G
Obesity surgery 2023
Combined Effect of Genetic Variants on Long-Term Weight Response after Bariatric Surgery
Torrego-Ellacuría M, Barabash A, Matía-Martín P, Sánchez-Pernaute A, Torres AJ, Calle-Pascual AL, Rubio-Herrera MA
Journal of Clinical Medicine 2023
Molecular remodeling of adipose tissue is associated with metabolic recovery after weight loss surgery.
Bouchard-Mercier A, de Toro-Martín J, Nadeau M, Lescelleur O, Lebel S, Richard D, Biertho L, Tchernof A, Vohl MC
Journal of Translational Medicine 2022
The Obesogenic and Glycemic Effect of Bariatric Surgery in a Family with a Melanocortin 4 Receptor Loss-of-Function Mutation
Grinbaum R, Beglaibter N, Mitrani-Rosenbaum S, Kaplan LM, Ben-Zvi D
Metabolites 2022
Higher Waist Hip Ratio Genetic Risk Score Is Associated with Reduced Weight Loss in Patients with Severe Obesity Completing a Meal Replacement Programme
Handley D, Rafey MF, Almansoori S, Brazil JF, McCarthy A, Amin HA, O\u2019Donnell M, Blakemore AI, Finucane FM
Journal of Personalized Medicine 2022
Elevated risk of attention deficit hyperactivity disorder (ADHD) in Japanese children with higher genetic susceptibility to ADHD with a birth weight under 2000 g
S Rahman, N Takahashi, T Iwabuchi, T Nishimura, T Harada, A Okumura, N Takei, Y Nomura, KJ Tsuchiya
BMC Medicine 2021
Genetic markers of abdominal obesity and weight loss after gastric bypass surgery
M Aasbrenn, M Svendstrup, TM Schnurr, DL Hansen, D Worm, M Balslev-Harder, N Grarup, KS Burgdorf, H Vestergaard, O Pedersen, L Ängquist, M Fenger, TI Sørensen, S Madsbad, T Hansen, S Rohrmann
PloS one 2021
Cost effectiveness analysis of a polygenic risk tailored breast cancer screening programme in Singapore
JZ Wong, JH Chai, YS Yeoh, NK Riza, J Liu, YY Teo, HL Wee, M Hartman
BMC health services research 2021
Comparison of Comorbidity Treatment and Costs Associated With Bariatric Surgery Among Adults With Obesity in Canada
JA Davis, R Saunders
2020
A Genetic Risk Score for the Estimation of Weight Loss After Bariatric Surgery
EA Katsareli, C Amerikanou, K Rouskas, A Dimopoulos, T Diamantis, A Alexandrou, J Griniatsos, S Bourgeois, E Dermitzakis, J Ragoussis, AS Dimas, GV Dedoussis
Obesity Surgery 2020
Association of Genetic Risks With Autism Spectrum Disorder and Early Neurodevelopmental Delays Among Children Without Intellectual Disability
N Takahashi, T Harada, T Nishimura, A Okumura, D Choi, T Iwabuchi, H Kuwabara, S Takagai, Y Nomura, N Takei, KJ Tsuchiya
2020
Impact of weight trajectory after bariatric surgery on co-morbidity evolution and burden
JA Davis, R Saunders
BMC health services research 2020
Earlier Provision of Gastric Bypass Surgery in Canada Enhances Surgical Benefit and Leads to Cost and Comorbidity Reduction
JA Davis, R Saunders
Frontiers in public health 2020
Genetic Determinants of Weight Loss After Bariatric Surgery
M Aasbrenn, TM Schnurr, CT Have, M Svendstrup, DL Hansen, D Worm, M Balslev-Harder, M Hollensted, N Grarup, KS Burgdorf, H Vestergaard, O Pedersen, TI Sørensen, M Fenger, S Madsbad, T Hansen
Obesity Surgery 2019
The Challenge of Stratifying Obesity: Attempts in the Quebec Family Study
J de Toro-Martín, F Guénard, C Bouchard, A Tremblay, L Pérusse, MC Vohl
Frontiers in Genetics 2019
Body mass index is associated with epigenetic age acceleration in the visceral adipose tissue of subjects with severe obesity
J de Toro-Martín, F Guénard, A Tchernof, FS Hould, S Lebel, F Julien, S Marceau, MC Vohl
Clinical Epigenetics 2019
Development of an Interactive Outcome Estimation Tool for Laparoscopic Roux-en-Y Gastric Bypass in Mexico Based on a Cohort of 1002 Patients
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Obesity Surgery 2019

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