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PPT1 inhibition enhances the antitumor activity of anti–PD-1 antibody in melanoma
Gaurav Sharma, … , Dmitry I. Gabrilovich, Ravi K. Amaravadi
Gaurav Sharma, … , Dmitry I. Gabrilovich, Ravi K. Amaravadi
Published October 24, 2022
Citation Information: JCI Insight. 2022;7(20):e165688. https://doi.org/10.1172/jci.insight.165688.
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PPT1 inhibition enhances the antitumor activity of anti–PD-1 antibody in melanoma

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Abstract

Authors

Gaurav Sharma, Rani Ojha, Estela Noguera-Ortega, Vito W. Rebecca, John Attanasio, Shujing Liu, Shengfu Piao, Jennifer J. Lee, Michael C. Nicastri, Sandra L. Harper, Amruta Ronghe, Vaibhav Jain, Jeffrey D. Winkler, David W. Speicher, Jerome Mastio, Phyllis A. Gimotty, Xiaowei Xu, E. John Wherry, Dmitry I. Gabrilovich, Ravi K. Amaravadi

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Markers of fungal translocation are elevated during post-acute sequelae of SARS-CoV-2 and induce NF-κB signaling
Leila B. Giron, … , Timothy J. Henrich, Mohamed Abdel-Mohsen
Leila B. Giron, … , Timothy J. Henrich, Mohamed Abdel-Mohsen
Published September 22, 2022
Citation Information: JCI Insight. 2022;7(18):e164813. https://doi.org/10.1172/jci.insight.164813.
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Markers of fungal translocation are elevated during post-acute sequelae of SARS-CoV-2 and induce NF-κB signaling

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Abstract

Authors

Leila B. Giron, Michael J. Peluso, Jianyi Ding, Grace Kenny, Netanel F. Zilberstein, Jane Koshy, Kai Ying Hong, Heather Rasmussen, Gregory E. Miller, Faraz Bishehsari, Robert A. Balk, James N. Moy, Rebecca Hoh, Scott Lu, Aaron R. Goldman, Hsin-Yao Tang, Brandon C. Yee, Ahmed Chenna, John W. Winslow, Christos J. Petropoulos, J. Daniel Kelly, Haimanot Wasse, Jeffrey N. Martin, Qin Liu, Ali Keshavarzian, Alan Landay, Steven G. Deeks, Timothy J. Henrich, Mohamed Abdel-Mohsen

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miR–9-5p regulates immunometabolic and epigenetic pathways in β-glucan–trained immunity via IDH3α
Haibo Su, … , Qing Gong, Ying Xu
Haibo Su, … , Qing Gong, Ying Xu
Published March 22, 2022
Citation Information: JCI Insight. 2022;7(6):e159640. https://doi.org/10.1172/jci.insight.159640.
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miR–9-5p regulates immunometabolic and epigenetic pathways in β-glucan–trained immunity via IDH3α

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Abstract

Authors

Haibo Su, Zhongping Liang, ShuFeng Weng, Chaonan Sun, Jiaxin Huang, TianRan Zhang, Xialian Wang, Shanshan Wu, Zhi Zhang, Yiqi Zhang, Qing Gong, Ying Xu

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Actin fence therapy with exogenous V12Rac1 protects against acute lung injury
Galina A. Gusarova, … , Sunita Bhattacharya, Jahar Bhattacharya
Galina A. Gusarova, … , Sunita Bhattacharya, Jahar Bhattacharya
Published April 22, 2021
Citation Information: JCI Insight. ;6(8):e150137. https://doi.org/10.1172/jci.insight.150137.
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Actin fence therapy with exogenous V12Rac1 protects against acute lung injury

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Abstract

Authors

Galina A. Gusarova, Shonit R. Das, Mohammad N. Islam, Kristin Westphalen, Guangchun Jin, Igor O. Shmarakov, Li Li, Sunita Bhattacharya, Jahar Bhattacharya

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The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance
Melinde Wijers, … , Jan Albert Kuivenhoven, Bart van de Sluis
Melinde Wijers, … , Jan Albert Kuivenhoven, Bart van de Sluis
Published April 8, 2021
Citation Information: JCI Insight. ;6(7):e149528. https://doi.org/10.1172/jci.insight.149528.
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The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance

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Authors

Melinde Wijers, Paolo Zanoni, Nalan Liv, Dyonne Y. Vos, Michelle Y. Jäckstein, Marieke Smit, Sanne Wilbrink, Justina C. Wolters, Ydwine T. van der Veen, Nicolette Huijkman, Daphne Dekker, Niels Kloosterhuis, Theo H. van Dijk, Daniel D. Billadeau, Folkert Kuipers, Judith Klumperman, Arnold von Eckardstein, Jan Albert Kuivenhoven, Bart van de Sluis

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Improving vascular maturation using noncoding RNAs increases antitumor effect of chemotherapy
Lingegowda S. Mangala, … , David G. Gorenstein, Anil K. Sood
Lingegowda S. Mangala, … , David G. Gorenstein, Anil K. Sood
Published April 1, 2021
Citation Information: JCI Insight. 2021;6(7):e149896. https://doi.org/10.1172/jci.insight.149896.
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Improving vascular maturation using noncoding RNAs increases antitumor effect of chemotherapy

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Authors

Lingegowda S. Mangala, Hongyu Wang, Dahai Jiang, Sherry Y. Wu, Anoma Somasunderam, David E. Volk, Ganesh L. R. Lokesh, Xin Li, Sunila Pradeep, Xianbin Yang, Monika Haemmerle, Cristian Rodriguez-Aguayo, Archana S Nagaraja, Rajesha Rupaimoole, Emine Bayraktar, Recep Bayraktar, Li Li, Takemi Tanaka, Wei Hu, Cristina Ivan, Kshipra M Gharpure, Michael H. McGuire, Varatharasa Thiviyanathan, Xinna Zhang, Sourindra N. Maiti, Nataliya Bulayeva, Hyun-Jin Choi, Piotr L. Dorniak, Laurence J.N. Cooper, Kevin P. Rosenblatt, Gabriel Lopez-Berestein, David G. Gorenstein, Anil K. Sood

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Adrenergic-mediated increases in INHBA drive CAF phenotype and collagens
Archana S. Nagaraja, … , Steve W. Cole, Anil K. Sood
Archana S. Nagaraja, … , Steve W. Cole, Anil K. Sood
Published April 1, 2021
Citation Information: JCI Insight. 2021;6(7):e149895. https://doi.org/10.1172/jci.insight.149895.
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Adrenergic-mediated increases in INHBA drive CAF phenotype and collagens

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Abstract

Authors

Archana S. Nagaraja, Robert L. Dood, Guillermo Armaiz-Pena, Yu Kang, Sherry Y. Wu, Julie K. Allen, Nicholas B. Jennings, Lingegowda S. Mangala, Sunila Pradeep, Yasmin Lyons, Monika Haemmerle, Kshipra M. Gharpure, Nouara C. Sadaoui, Cristian Rodriguez-Aguayo, Cristina Ivan, Ying Wang, Keith Baggerly, Prahlad Ram, Gabriel Lopez-Berestein, Jinsong Liu, Samuel C. Mok, Lorenzo Cohen, Susan K. Lutgendorf, Steve W. Cole, Anil K. Sood

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MERTK inhibition alters the PD-1 axis and promotes anti-leukemia immunity
Alisa B. Lee-Sherick, … , Deborah DeRyckere, Douglas K. Graham
Alisa B. Lee-Sherick, … , Deborah DeRyckere, Douglas K. Graham
Published December 3, 2020
Citation Information: JCI Insight. 2020;5(23):e145847. https://doi.org/10.1172/jci.insight.145847.
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MERTK inhibition alters the PD-1 axis and promotes anti-leukemia immunity

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Abstract

Authors

Alisa B. Lee-Sherick, Kristen M. Jacobsen, Curtis J. Henry, Madeline G. Huey, Rebecca E. Parker, Lauren S. Page, Amanda A. Hill, Xiaodong Wang, Stephen V. Frye, H. Shelton Earp, Craig T. Jordan, Deborah DeRyckere, Douglas K. Graham

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Epstein-Barr virus–specific T cell therapy for progressive multiple sclerosis
Michael P. Pender, … , Alan Coulthard, Rajiv Khanna
Michael P. Pender, … , Alan Coulthard, Rajiv Khanna
Published October 15, 2020
Citation Information: JCI Insight. 2020;5(20):e144624. https://doi.org/10.1172/jci.insight.144624.
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Epstein-Barr virus–specific T cell therapy for progressive multiple sclerosis

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Abstract

Authors

Michael P. Pender, Peter A. Csurhes, Corey Smith, Nanette L. Douglas, Michelle A. Neller, Katherine K. Matthews, Leone Beagley, Sweera Rehan, Pauline Crooks, Tracey J. Hopkins, Stefan Blum, Kerryn A. Green, Zara A. Ioannides, Andrew Swayne, Blake T. Aftab, Kaye D. Hooper, Scott R. Burrows, Kate M. Thompson, Alan Coulthard, Rajiv Khanna

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Gut microbiota–dependent modulation of innate immunity and lymph node remodeling affects cardiac allograft outcomes
Jonathan S. Bromberg, … , Colin C. Brinkman, Emmanuel F. Mongodin
Jonathan S. Bromberg, … , Colin C. Brinkman, Emmanuel F. Mongodin
Published August 6, 2020
Citation Information: JCI Insight. 2020;5(15):e142528. https://doi.org/10.1172/jci.insight.142528.
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Gut microbiota–dependent modulation of innate immunity and lymph node remodeling affects cardiac allograft outcomes

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Abstract

Authors

Jonathan S. Bromberg, Lauren Hittle, Yanbao Xiong, Vikas Saxena, Eoghan M. Smyth, Lushen Li, Tianshu Zhang, Chelsea Wagner, W. Florian Fricke, Thomas Simon, Colin C. Brinkman, Emmanuel F. Mongodin

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