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Diabetic retinopathy: current understanding, mechanisms, and treatment strategies
Elia J. Duh, … , Jennifer K. Sun, Alan W. Stitt
Elia J. Duh, … , Jennifer K. Sun, Alan W. Stitt
Published July 20, 2017
Citation Information: JCI Insight. 2017;2(14):e93751. https://doi.org/10.1172/jci.insight.93751.
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Diabetic retinopathy: current understanding, mechanisms, and treatment strategies

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Abstract

Diabetic retinopathy (DR) causes significant visual loss on a global scale. Treatments for the vision-threatening complications of diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) have greatly improved over the past decade. However, additional therapeutic options are needed that take into account pathology associated with vascular, glial, and neuronal components of the diabetic retina. Recent work indicates that diabetes markedly impacts the retinal neurovascular unit and its interdependent vascular, neuronal, glial, and immune cells. This knowledge is leading to identification of new targets and therapeutic strategies for preventing or reversing retinal neuronal dysfunction, vascular leakage, ischemia, and pathologic angiogenesis. These advances, together with approaches embracing the potential of preventative or regenerative medicine, could provide the means to better manage DR, including treatment at earlier stages and more precise tailoring of treatments based on individual patient variations.

Authors

Elia J. Duh, Jennifer K. Sun, Alan W. Stitt

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Figure 1

Pathological lesions of diabetic retinopathy.

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Pathological lesions of diabetic retinopathy.
(A) An illustrated schemat...
(A) An illustrated schematic of normal retina compared with nonproliferative diabetic retinopathy (NPDR) with diabetic macular edema (DME). The normal healthy retina includes healthy retinal blood vessels, glial elements including Müller cells, neuronal elements including photoreceptors, and resting microglia. The inner and outer blood-retinal barriers are intact. In contrast, the retina in diabetic retinopathy exhibits multiple abnormalities, including vascular changes (microaneurysms, venous beading, capillary degeneration, and neovascularization), lesions associated with vascular damage (cotton wool spots and exudate), glial dysfunction including Müller cell swelling, neuronal damage, activated microglia, retinal pigment epithelium (RPE) damage, and thinning of the choriocapillaris. There is dysfunction of the inner and outer blood-retinal barrier, with resulting accumulation of fluid in the retina, which can be manifested by thickening of retinal layers, cysts, and subretinal fluid. (B) Color fundus photograph and OCT images of a normal healthy retina and retina with severe NPDR with central-involved DME are shown. Illustrated by Rachel Davidowitz.

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