JCI Insight - Refining cell-type annotation and fibrotic comparisons in chronic lung allograft dysfunction in single-cell RNA-seq studies

Refining cell-type annotation and fibrotic comparisons in chronic lung allograft dysfunction in single-cell RNA-seq studies

Allen Duong, Sajad Moshkelgosha, Tereza Martinu, Stephen Juvet

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Figure 1

Expression of Super.Macro/ISG macrophage markers in ALAD BAL and CLAD lungs.

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(A) Uniform manifold approximation and projection (UMAP) plot displaying myeloid cells from ALAD BAL (left) and integrated CLAD lung (right) datasets, split by dataset and sample origin. (B and C) Dot plots showing the expression of Super.Macro/ISG macrophage-associated genes across monocyte/macrophage populations in BAL (B) and CLAD lung (C) datasets. Dot size represents the percentage of cells expressing each gene, and dot color represents the averaged scaled expression level. (D and E) Feature plots highlighting expression and distribution of Super.Macro/ISG macrophage-associated genes in BAL (D) and lung (E) datasets. Lung feature plots are displayed separately for Moshkelgosha et al. (2) and Yan et al. (1) cohorts.

Refining cell-type annotation and fibrotic comparisons in chronic lung allograft dysfunction in single-cell RNA-seq studies

Refining cell-type annotation and fibrotic comparisons in chronic lung allograft dysfunction in single-cell RNA-seq studies

Abstract

Authors

Figure 1

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