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Admissions to MD-PhD programs: how well do application metrics predict short- or long-term physician-scientist outcomes?
Lawrence F. Brass, … , Aislinn Wallace, Myles H. Akabas
Lawrence F. Brass, … , Aislinn Wallace, Myles H. Akabas
Published March 4, 2025
Citation Information: JCI Insight. 2025;10(7):e184493. https://doi.org/10.1172/jci.insight.184493.
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Physician-Scientist Development

Admissions to MD-PhD programs: how well do application metrics predict short- or long-term physician-scientist outcomes?

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Abstract

MD-PhD programs prepare physicians for research-focused careers. The challenge for admissions committees is to select from among their applicants those who will achieve this goal, becoming leaders in academic medicine and biomedical research. Although holistic practices are encouraged, the temptation remains to use metrics such as grade point average, Medical College Admission Test scores, and postbaccalaureate gap length, combined with race and ethnicity, age at college graduation, and sex to select whom to interview and admit. Here, we asked whether any of these metrics predict performance in training or career paths after graduation. Data were drawn from the National MD-PhD Program Outcomes Study with information on 4,659 alumni and 593 MD-PhD graduates of the Albert Einstein College of Medicine and the University of Pennsylvania. The Penn-Einstein dataset included admissions committee summative scores, attrition, and the number and impact of PhD publications. Output metrics included time to degree, eventual employment in workplaces consistent with MD-PhD training goals, and self-reported research effort. Data were analyzed using machine learning and multivariate linear regression. The results show that none of the applicant metrics, individually or collectively, predicted in-program performance, future research effort, or eventual workplace choices even when comparisons were limited to those in the top and bottom quintiles.

Authors

Lawrence F. Brass, Maurizio Tomaiuolo, Aislinn Wallace, Myles H. Akabas

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Figure 4

National dataset applicant metrics do not predict outcomes after completion of postgraduate training including favorable workplace or self-reported research effort for graduates in favorable workplaces, and the more extensive applicant metrics for the Penn-Einstein dataset, including publications during PhD, do not predict favorable workplace following completion of postgraduate training.

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National dataset applicant metrics do not predict outcomes after complet...
(A–C) ROC curves for machine learning analysis prediction of indicated outcome based on the input metrics listed under Features in D. Colors and interpretation are as in Figure 3’s legend. (A) ROC curve for prediction of the eventual choice of a research-oriented workplace after completion of postgraduate training using the national dataset. (B) ROC curve for prediction of research effort classified as favorable (≥50%) or unfavorable (<50%) for graduates in favorable workplaces. (C) ROC curve for prediction of favorable workplace from Penn-Einstein dataset. (D) The dataset used, the favorable versus unfavorable outcome metric (Table 1), input features (i.e., applicant metrics), and classifier results for A–C.

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