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Admissions to MD-PhD programs: how well do application metrics predict short- or long-term physician-scientist outcomes?
Lawrence F. Brass, … , Aislinn Wallace, Myles H. Akabas
Lawrence F. Brass, … , Aislinn Wallace, Myles H. Akabas
Published March 4, 2025
Citation Information: JCI Insight. 2025;10(7):e184493. https://doi.org/10.1172/jci.insight.184493.
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Physician-Scientist Development

Admissions to MD-PhD programs: how well do application metrics predict short- or long-term physician-scientist outcomes?

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Abstract

MD-PhD programs prepare physicians for research-focused careers. The challenge for admissions committees is to select from among their applicants those who will achieve this goal, becoming leaders in academic medicine and biomedical research. Although holistic practices are encouraged, the temptation remains to use metrics such as grade point average, Medical College Admission Test scores, and postbaccalaureate gap length, combined with race and ethnicity, age at college graduation, and sex to select whom to interview and admit. Here, we asked whether any of these metrics predict performance in training or career paths after graduation. Data were drawn from the National MD-PhD Program Outcomes Study with information on 4,659 alumni and 593 MD-PhD graduates of the Albert Einstein College of Medicine and the University of Pennsylvania. The Penn-Einstein dataset included admissions committee summative scores, attrition, and the number and impact of PhD publications. Output metrics included time to degree, eventual employment in workplaces consistent with MD-PhD training goals, and self-reported research effort. Data were analyzed using machine learning and multivariate linear regression. The results show that none of the applicant metrics, individually or collectively, predicted in-program performance, future research effort, or eventual workplace choices even when comparisons were limited to those in the top and bottom quintiles.

Authors

Lawrence F. Brass, Maurizio Tomaiuolo, Aislinn Wallace, Myles H. Akabas

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Figure 2

Distributions of input variables for the national dataset population based on favorable or unfavorable current workplace (Table 1) and possible correlations between pairs of input variables from the national dataset.

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Distributions of input variables for the national dataset population bas...
(A–E) Histograms of input variable for favorable workplace (purple), unfavorable workplace (yellow), and the overlap (brown). P value above each panel indicates the significance of the difference between favorable or unfavorable distributions. Distributions of (A) MCATM77 scores, (B) MCAT1991 scores, (C) undergraduate GPA, (D) length of gap between undergraduate college graduation year and MD-PhD matriculation year, and (E) TTD calculated by year of MD-PhD graduation minus year of matriculation. (F) Mean of favorable and unfavorable groups and number of individuals for each variable. (G–L) Scatterplots for pairs of variables. The Spearman’s rho parameter is shown above each panel. For a perfect monotonic relationship between 2 variables, the Spearman’s rho coefficient would be 1 or –1 for a positive or negative correlation, respectively. A Spearman’s rho coefficient close to 0 indicates no correlation. The panels show scatterplots between data pairs (G) GPA and MCATM77, (H) GPA and MCAT1991, (I) GPA and gap length in years, (J) GPA and TTD, (K) MCATM77 and TTD, and (L) MCAT1991 and TTD. Because MCAT scores from different versions of the exam, MCATM77 and MCAT1991, have different content and the scores are not directly comparable, we analyzed them separately. The maximum number of points in each plot is shown in F.

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