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Hypoxia and viral infectious diseases
Richard Huang, … , Eng Eong Ooi, Michael Ohh
Richard Huang, … , Eng Eong Ooi, Michael Ohh
Published April 8, 2021
Citation Information: JCI Insight. 2021;6(7):e147190. https://doi.org/10.1172/jci.insight.147190.
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Hypoxia and viral infectious diseases

Abstract

Oxygen-sensing mechanisms allow cells to adapt and respond to changes in cellular oxygen tension, including hypoxic conditions. Hypoxia-inducible factor (HIF) is a central mediator in this fundamental adaptive response, and has critical functions in normal and disease physiology. Viruses have been shown to manipulate HIFs during their life cycle to facilitate replication and invasion. Conversely, HIFs are also implicated in the development of the host immune system and response to viral infections. Here, we highlight the recent revelations of host-pathogen interactions that involve the hypoxic response pathway and the role of HIF in emerging viral infectious diseases, as well as discussing potential antiviral therapeutic strategies targeting the HIF signaling axis.

Authors

Richard Huang, Melissa Huestis, Esther Shuyi Gan, Eng Eong Ooi, Michael Ohh

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