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Usage Information

Therapeutic manipulation of innate lymphoid cells
Laura M. Cobb, Michael R. Verneris
Laura M. Cobb, Michael R. Verneris
Published March 22, 2021
Citation Information: JCI Insight. 2021;6(6):e146006. https://doi.org/10.1172/jci.insight.146006.
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Review

Therapeutic manipulation of innate lymphoid cells

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Abstract

Since their relatively recent discovery, innate lymphoid cells (ILCs) have been shown to be tissue-resident lymphocytes that are critical mediators of tissue homeostasis, regeneration, and pathogen response. However, ILC dysregulation contributes to a diverse spectrum of human diseases, spanning virtually every organ system. ILCs rapidly respond to environmental cues by altering their own phenotype and function as well as influencing the behavior of other local tissue-resident cells. With a growing understanding of ILC biology, investigators continue to elucidate mechanisms that expand our ability to phenotype, isolate, target, and expand ILCs ex vivo. With mounting preclinical data and clinical correlates, the role of ILCs in both disease pathogenesis and resolution is evident, justifying ILC manipulation for clinical benefit. This Review will highlight areas of ongoing translational research and critical questions for future study that will enable us to harness the full therapeutic potential of these captivating cells.

Authors

Laura M. Cobb, Michael R. Verneris

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Usage data is cumulative from September 2022 through September 2023.

Usage JCI PMC
Text version 1,162 482
PDF 184 95
Figure 265 1
Table 154 0
Citation downloads 29 0
Totals 1,794 578
Total Views 2,372

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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