Go to The Journal of Clinical Investigation
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Transfers
  • Advertising
  • Job board
  • Contact
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Immunology
    • Metabolism
    • Nephrology
    • Oncology
    • Pulmonology
    • All ...
  • Videos
  • Collections
    • Resource and Technical Advances
    • Clinical Medicine
    • Reviews
    • Editorials
    • Perspectives
    • Top read articles
  • JCI This Month
    • Current issue
    • Past issues

  • Current issue
  • Past issues
  • Specialties
  • In-Press Preview
  • Editorials
  • Viewpoint
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Transfers
  • Advertising
  • Job board
  • Contact
New (re)purpose for an old drug: purinergic modulation may extinguish the COVID-19 thromboinflammatory firestorm
Yogendra Kanthi, … , Yu Zuo, David J. Pinsky
Yogendra Kanthi, … , Yu Zuo, David J. Pinsky
Published June 12, 2020
Citation Information: JCI Insight. 2020;5(14):e140971. https://doi.org/10.1172/jci.insight.140971.
View: Text | PDF
Perspective

New (re)purpose for an old drug: purinergic modulation may extinguish the COVID-19 thromboinflammatory firestorm

  • Text
  • PDF
Abstract

Authors

Yogendra Kanthi, Jason S. Knight, Yu Zuo, David J. Pinsky

×

Figure 1

Dipyridamole’s mechanisms of action and potential role in the treatment of COVID-19.

Options: View larger image (or click on image) Download as PowerPoint
Dipyridamole’s mechanisms of action and potential role in the treatment ...
(A) Dipyridamole potentiates homeostatic adenosine receptor signaling by preventing reuptake of ectonucleoside (i) and by stabilizing the intracellular cAMP pools via inhibition of cytoplasmic phosphodiesterase (PDE) activity (ii). (B) Left unchecked, purinergic signaling exacerbates both inflammation and thrombosis; therefore, dipyridamole has the potential to inhibit multiple processes that have been recently linked to COVID-19 severity. Illustrated by Rachel Davidowitz.

Copyright © 2023 American Society for Clinical Investigation
ISSN 2379-3708

Sign up for email alerts