Genetic and environmental factors underlying keratinocyte carcinoma risk
Hélène Choquet, … , Maryam M. Asgari, Eric Jorgenson
Hélène Choquet, … , Maryam M. Asgari, Eric Jorgenson
Published May 21, 2020
Citation Information: JCI Insight. 2020;5(10):e134783. https://doi.org/10.1172/jci.insight.134783.
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Review

Genetic and environmental factors underlying keratinocyte carcinoma risk

Abstract

Recent large-scale GWAS and large epidemiologic studies have accelerated the discovery of genes and environmental factors that contribute to the risk of keratinocyte carcinoma (KC), which includes basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). This Review summarizes the genomic regions associated with SCC and BCC risk, examines the genetic overlap between SCC and BCC, and discusses biological pathways involved in SCC and BCC development. Next, we review environmental factors that are associated with KC risk, including those that are shared between SCC and BCC as well as others that associated with only one type of KC. We conclude with a critical appraisal of current research and potential directions for future research.

Authors

Hélène Choquet, Sepideh Ashrafzadeh, Yuhree Kim, Maryam M. Asgari, Eric Jorgenson

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Figure 1

Normal skin structure and keratinocyte carcinomas.

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Normal skin structure and keratinocyte carcinomas. (A) Normal skin archi...
(A) Normal skin architecture showing composition of the dermis and epidermis (magnification 10×). The epidermis contains keratinocytes, which give rise to (B) squamous cell carcinoma (magnification 40×) and (C) basal cell carcinoma (magnification 40×). Images of SCC and BCC were taken from the National Cancer Institute (https://www.cancer.gov). Illustrated by Rachel Davidowitz.