ResearchIn-Press PreviewBone biology
Open Access | 
10.1172/jci.insight.198245
GALNT1 drives aggressive phenotypes of rheumatoid synoviocytes via NEK9 O‑glycosylation
Yaoyao Zou,1 Haobo Lin,1 Jianling Su,1 Jieying Wang,1 Qin Zeng,1 Tianxiao Feng,1 Yunxia Lei,1 Jianda Ma,2 Hudan Pan,3 Hanshi Xu,4 Lie Dai,1 and Yang Li5
1Department of Rheumatology and Immunology, Southern Medical University, Guangzhou, China
2Department of Rheumatology, Sun Yat-Sen University, Guangzhou, China
3State Key Laboratory of Traditional Chinese Medicine Syndrome, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
4Department of Rheumatology and Immunology, Sun Yat-Sen University, Guangzhou, China
5Department of Rheumatology and Immunology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Find articles by Zou, Y. in: PubMed | Google Scholar
1Department of Rheumatology and Immunology, Southern Medical University, Guangzhou, China
2Department of Rheumatology, Sun Yat-Sen University, Guangzhou, China
3State Key Laboratory of Traditional Chinese Medicine Syndrome, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
4Department of Rheumatology and Immunology, Sun Yat-Sen University, Guangzhou, China
5Department of Rheumatology and Immunology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Find articles by Lin, H. in: PubMed | Google Scholar
1Department of Rheumatology and Immunology, Southern Medical University, Guangzhou, China
2Department of Rheumatology, Sun Yat-Sen University, Guangzhou, China
3State Key Laboratory of Traditional Chinese Medicine Syndrome, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
4Department of Rheumatology and Immunology, Sun Yat-Sen University, Guangzhou, China
5Department of Rheumatology and Immunology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Find articles by Su, J. in: PubMed | Google Scholar
1Department of Rheumatology and Immunology, Southern Medical University, Guangzhou, China
2Department of Rheumatology, Sun Yat-Sen University, Guangzhou, China
3State Key Laboratory of Traditional Chinese Medicine Syndrome, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
4Department of Rheumatology and Immunology, Sun Yat-Sen University, Guangzhou, China
5Department of Rheumatology and Immunology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Find articles by Wang, J. in: PubMed | Google Scholar
1Department of Rheumatology and Immunology, Southern Medical University, Guangzhou, China
2Department of Rheumatology, Sun Yat-Sen University, Guangzhou, China
3State Key Laboratory of Traditional Chinese Medicine Syndrome, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
4Department of Rheumatology and Immunology, Sun Yat-Sen University, Guangzhou, China
5Department of Rheumatology and Immunology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Find articles by Zeng, Q. in: PubMed | Google Scholar
1Department of Rheumatology and Immunology, Southern Medical University, Guangzhou, China
2Department of Rheumatology, Sun Yat-Sen University, Guangzhou, China
3State Key Laboratory of Traditional Chinese Medicine Syndrome, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
4Department of Rheumatology and Immunology, Sun Yat-Sen University, Guangzhou, China
5Department of Rheumatology and Immunology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Find articles by Feng, T. in: PubMed | Google Scholar
1Department of Rheumatology and Immunology, Southern Medical University, Guangzhou, China
2Department of Rheumatology, Sun Yat-Sen University, Guangzhou, China
3State Key Laboratory of Traditional Chinese Medicine Syndrome, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
4Department of Rheumatology and Immunology, Sun Yat-Sen University, Guangzhou, China
5Department of Rheumatology and Immunology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Find articles by Lei, Y. in: PubMed | Google Scholar
1Department of Rheumatology and Immunology, Southern Medical University, Guangzhou, China
2Department of Rheumatology, Sun Yat-Sen University, Guangzhou, China
3State Key Laboratory of Traditional Chinese Medicine Syndrome, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
4Department of Rheumatology and Immunology, Sun Yat-Sen University, Guangzhou, China
5Department of Rheumatology and Immunology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Find articles by Ma, J. in: PubMed | Google Scholar
1Department of Rheumatology and Immunology, Southern Medical University, Guangzhou, China
2Department of Rheumatology, Sun Yat-Sen University, Guangzhou, China
3State Key Laboratory of Traditional Chinese Medicine Syndrome, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
4Department of Rheumatology and Immunology, Sun Yat-Sen University, Guangzhou, China
5Department of Rheumatology and Immunology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Find articles by Pan, H. in: PubMed | Google Scholar
1Department of Rheumatology and Immunology, Southern Medical University, Guangzhou, China
2Department of Rheumatology, Sun Yat-Sen University, Guangzhou, China
3State Key Laboratory of Traditional Chinese Medicine Syndrome, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
4Department of Rheumatology and Immunology, Sun Yat-Sen University, Guangzhou, China
5Department of Rheumatology and Immunology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Find articles by Xu, H. in: PubMed | Google Scholar
1Department of Rheumatology and Immunology, Southern Medical University, Guangzhou, China
2Department of Rheumatology, Sun Yat-Sen University, Guangzhou, China
3State Key Laboratory of Traditional Chinese Medicine Syndrome, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
4Department of Rheumatology and Immunology, Sun Yat-Sen University, Guangzhou, China
5Department of Rheumatology and Immunology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Find articles by Dai, L. in: PubMed | Google Scholar
1Department of Rheumatology and Immunology, Southern Medical University, Guangzhou, China
2Department of Rheumatology, Sun Yat-Sen University, Guangzhou, China
3State Key Laboratory of Traditional Chinese Medicine Syndrome, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
4Department of Rheumatology and Immunology, Sun Yat-Sen University, Guangzhou, China
5Department of Rheumatology and Immunology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Find articles by Li, Y. in: PubMed | Google Scholar
Published April 23, 2026 - More info
Copyright © 2026, Zou et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
