ResearchIn-Press PreviewAgingEndocrinology
Open Access | 
10.1172/jci.insight.192827
Palmitate impairs autophagic degradation via oxidative stress-perilysosomal Ca2+ overload-mTORC1 activation in pancreatic β-cells
Ha Thu Nguyen,1 Luong Dai Ly,1 Thuy Thi Thanh Ngo,1 Soo Kyung Lee,1 Carlos Noriega Polo,1 Subo Lee,1 Taesic Lee,2 Seung-Kuy Cha,1 Xaviera Riani Yasasilka,3 Kae Won Cho,3 Myung-Shik Lee,3 Andreas Wiederkehr,4 Claes B. Wollheim,5 and Kyu-Sang Park1
1Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of
2Department of Family Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of
3Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan, Korea, Republic of
4Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
5Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
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1Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of
2Department of Family Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of
3Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan, Korea, Republic of
4Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
5Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
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1Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of
2Department of Family Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of
3Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan, Korea, Republic of
4Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
5Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
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1Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of
2Department of Family Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of
3Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan, Korea, Republic of
4Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
5Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
Find articles by Lee, S. in: PubMed | Google Scholar
1Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of
2Department of Family Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of
3Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan, Korea, Republic of
4Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
5Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
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1Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of
2Department of Family Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of
3Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan, Korea, Republic of
4Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
5Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
Find articles by Lee, S. in: PubMed | Google Scholar
1Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of
2Department of Family Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of
3Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan, Korea, Republic of
4Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
5Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
Find articles by Lee, T. in: PubMed | Google Scholar
1Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of
2Department of Family Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of
3Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan, Korea, Republic of
4Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
5Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
Find articles by Cha, S. in: PubMed | Google Scholar
1Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of
2Department of Family Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of
3Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan, Korea, Republic of
4Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
5Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
Find articles by Yasasilka, X. in: PubMed | Google Scholar
1Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of
2Department of Family Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of
3Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan, Korea, Republic of
4Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
5Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
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Cho, K.
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1Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of
2Department of Family Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of
3Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan, Korea, Republic of
4Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
5Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
Find articles by Lee, M. in: PubMed | Google Scholar
1Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of
2Department of Family Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of
3Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan, Korea, Republic of
4Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
5Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
Find articles by Wiederkehr, A. in: PubMed | Google Scholar
1Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of
2Department of Family Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of
3Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan, Korea, Republic of
4Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
5Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
Find articles by Wollheim, C. in: PubMed | Google Scholar
1Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of
2Department of Family Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of
3Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan, Korea, Republic of
4Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
5Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
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Park, K.
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Published November 11, 2025 - More info
Copyright © 2025, Nguyen et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
