ResearchIn-Press PreviewCell biologyOncology
Open Access | 
10.1172/jci.insight.192113
Anoikis resistance and metastasis of ovarian cancer can be overcome by CDK8/19 Mediator kinase inhibition
Mehri Monavarian,1 Resha Rajkarnikar,1 Emily Faith Page,1 Asha Kumari,1 Liz Quintero Macias,1 Felipe Massicano,2 Nam Y. Lee,3 Sarthak Sahoo,4 Nadine Hempel,5 Mohit Kumar Jolly,4 Lara Ianov,2 Elizabeth Worthey,2 Abhyudai Singh,6 Igor B. Roninson,7 Eugenia V. Broude,7 Mengqian Chen,7 and Karthikeyan Mythreye1
1Division of Molecular Cellular Pathology, Department of Pathology, O'Neal Cancer Center, University of Alabama, Heersink School of Medicine, Birmingham, United States of America
2UAB Biological Data Science Core, The University of Alabama at Birmingham, Birmingham, United States of America
3Division of Pharmacology, Chemistry and Biochemistry, College of Medicine, University of Arizona, Tucson, United States of America
4Department of Bioengineering, Indian Institute of Science, Bangalore, India
5Department of Medicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
6Department of Electrical and Computer Engineering, University of Delaware, Newark, United States of America
7Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, United States of America
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1Division of Molecular Cellular Pathology, Department of Pathology, O'Neal Cancer Center, University of Alabama, Heersink School of Medicine, Birmingham, United States of America
2UAB Biological Data Science Core, The University of Alabama at Birmingham, Birmingham, United States of America
3Division of Pharmacology, Chemistry and Biochemistry, College of Medicine, University of Arizona, Tucson, United States of America
4Department of Bioengineering, Indian Institute of Science, Bangalore, India
5Department of Medicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
6Department of Electrical and Computer Engineering, University of Delaware, Newark, United States of America
7Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, United States of America
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1Division of Molecular Cellular Pathology, Department of Pathology, O'Neal Cancer Center, University of Alabama, Heersink School of Medicine, Birmingham, United States of America
2UAB Biological Data Science Core, The University of Alabama at Birmingham, Birmingham, United States of America
3Division of Pharmacology, Chemistry and Biochemistry, College of Medicine, University of Arizona, Tucson, United States of America
4Department of Bioengineering, Indian Institute of Science, Bangalore, India
5Department of Medicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
6Department of Electrical and Computer Engineering, University of Delaware, Newark, United States of America
7Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, United States of America
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1Division of Molecular Cellular Pathology, Department of Pathology, O'Neal Cancer Center, University of Alabama, Heersink School of Medicine, Birmingham, United States of America
2UAB Biological Data Science Core, The University of Alabama at Birmingham, Birmingham, United States of America
3Division of Pharmacology, Chemistry and Biochemistry, College of Medicine, University of Arizona, Tucson, United States of America
4Department of Bioengineering, Indian Institute of Science, Bangalore, India
5Department of Medicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
6Department of Electrical and Computer Engineering, University of Delaware, Newark, United States of America
7Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, United States of America
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1Division of Molecular Cellular Pathology, Department of Pathology, O'Neal Cancer Center, University of Alabama, Heersink School of Medicine, Birmingham, United States of America
2UAB Biological Data Science Core, The University of Alabama at Birmingham, Birmingham, United States of America
3Division of Pharmacology, Chemistry and Biochemistry, College of Medicine, University of Arizona, Tucson, United States of America
4Department of Bioengineering, Indian Institute of Science, Bangalore, India
5Department of Medicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
6Department of Electrical and Computer Engineering, University of Delaware, Newark, United States of America
7Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, United States of America
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1Division of Molecular Cellular Pathology, Department of Pathology, O'Neal Cancer Center, University of Alabama, Heersink School of Medicine, Birmingham, United States of America
2UAB Biological Data Science Core, The University of Alabama at Birmingham, Birmingham, United States of America
3Division of Pharmacology, Chemistry and Biochemistry, College of Medicine, University of Arizona, Tucson, United States of America
4Department of Bioengineering, Indian Institute of Science, Bangalore, India
5Department of Medicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
6Department of Electrical and Computer Engineering, University of Delaware, Newark, United States of America
7Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, United States of America
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1Division of Molecular Cellular Pathology, Department of Pathology, O'Neal Cancer Center, University of Alabama, Heersink School of Medicine, Birmingham, United States of America
2UAB Biological Data Science Core, The University of Alabama at Birmingham, Birmingham, United States of America
3Division of Pharmacology, Chemistry and Biochemistry, College of Medicine, University of Arizona, Tucson, United States of America
4Department of Bioengineering, Indian Institute of Science, Bangalore, India
5Department of Medicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
6Department of Electrical and Computer Engineering, University of Delaware, Newark, United States of America
7Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, United States of America
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1Division of Molecular Cellular Pathology, Department of Pathology, O'Neal Cancer Center, University of Alabama, Heersink School of Medicine, Birmingham, United States of America
2UAB Biological Data Science Core, The University of Alabama at Birmingham, Birmingham, United States of America
3Division of Pharmacology, Chemistry and Biochemistry, College of Medicine, University of Arizona, Tucson, United States of America
4Department of Bioengineering, Indian Institute of Science, Bangalore, India
5Department of Medicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
6Department of Electrical and Computer Engineering, University of Delaware, Newark, United States of America
7Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, United States of America
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1Division of Molecular Cellular Pathology, Department of Pathology, O'Neal Cancer Center, University of Alabama, Heersink School of Medicine, Birmingham, United States of America
2UAB Biological Data Science Core, The University of Alabama at Birmingham, Birmingham, United States of America
3Division of Pharmacology, Chemistry and Biochemistry, College of Medicine, University of Arizona, Tucson, United States of America
4Department of Bioengineering, Indian Institute of Science, Bangalore, India
5Department of Medicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
6Department of Electrical and Computer Engineering, University of Delaware, Newark, United States of America
7Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, United States of America
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1Division of Molecular Cellular Pathology, Department of Pathology, O'Neal Cancer Center, University of Alabama, Heersink School of Medicine, Birmingham, United States of America
2UAB Biological Data Science Core, The University of Alabama at Birmingham, Birmingham, United States of America
3Division of Pharmacology, Chemistry and Biochemistry, College of Medicine, University of Arizona, Tucson, United States of America
4Department of Bioengineering, Indian Institute of Science, Bangalore, India
5Department of Medicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
6Department of Electrical and Computer Engineering, University of Delaware, Newark, United States of America
7Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, United States of America
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1Division of Molecular Cellular Pathology, Department of Pathology, O'Neal Cancer Center, University of Alabama, Heersink School of Medicine, Birmingham, United States of America
2UAB Biological Data Science Core, The University of Alabama at Birmingham, Birmingham, United States of America
3Division of Pharmacology, Chemistry and Biochemistry, College of Medicine, University of Arizona, Tucson, United States of America
4Department of Bioengineering, Indian Institute of Science, Bangalore, India
5Department of Medicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
6Department of Electrical and Computer Engineering, University of Delaware, Newark, United States of America
7Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, United States of America
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1Division of Molecular Cellular Pathology, Department of Pathology, O'Neal Cancer Center, University of Alabama, Heersink School of Medicine, Birmingham, United States of America
2UAB Biological Data Science Core, The University of Alabama at Birmingham, Birmingham, United States of America
3Division of Pharmacology, Chemistry and Biochemistry, College of Medicine, University of Arizona, Tucson, United States of America
4Department of Bioengineering, Indian Institute of Science, Bangalore, India
5Department of Medicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
6Department of Electrical and Computer Engineering, University of Delaware, Newark, United States of America
7Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, United States of America
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1Division of Molecular Cellular Pathology, Department of Pathology, O'Neal Cancer Center, University of Alabama, Heersink School of Medicine, Birmingham, United States of America
2UAB Biological Data Science Core, The University of Alabama at Birmingham, Birmingham, United States of America
3Division of Pharmacology, Chemistry and Biochemistry, College of Medicine, University of Arizona, Tucson, United States of America
4Department of Bioengineering, Indian Institute of Science, Bangalore, India
5Department of Medicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
6Department of Electrical and Computer Engineering, University of Delaware, Newark, United States of America
7Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, United States of America
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1Division of Molecular Cellular Pathology, Department of Pathology, O'Neal Cancer Center, University of Alabama, Heersink School of Medicine, Birmingham, United States of America
2UAB Biological Data Science Core, The University of Alabama at Birmingham, Birmingham, United States of America
3Division of Pharmacology, Chemistry and Biochemistry, College of Medicine, University of Arizona, Tucson, United States of America
4Department of Bioengineering, Indian Institute of Science, Bangalore, India
5Department of Medicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
6Department of Electrical and Computer Engineering, University of Delaware, Newark, United States of America
7Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, United States of America
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1Division of Molecular Cellular Pathology, Department of Pathology, O'Neal Cancer Center, University of Alabama, Heersink School of Medicine, Birmingham, United States of America
2UAB Biological Data Science Core, The University of Alabama at Birmingham, Birmingham, United States of America
3Division of Pharmacology, Chemistry and Biochemistry, College of Medicine, University of Arizona, Tucson, United States of America
4Department of Bioengineering, Indian Institute of Science, Bangalore, India
5Department of Medicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
6Department of Electrical and Computer Engineering, University of Delaware, Newark, United States of America
7Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, United States of America
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1Division of Molecular Cellular Pathology, Department of Pathology, O'Neal Cancer Center, University of Alabama, Heersink School of Medicine, Birmingham, United States of America
2UAB Biological Data Science Core, The University of Alabama at Birmingham, Birmingham, United States of America
3Division of Pharmacology, Chemistry and Biochemistry, College of Medicine, University of Arizona, Tucson, United States of America
4Department of Bioengineering, Indian Institute of Science, Bangalore, India
5Department of Medicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
6Department of Electrical and Computer Engineering, University of Delaware, Newark, United States of America
7Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, United States of America
Find articles by Chen, M. in: PubMed | Google Scholar
1Division of Molecular Cellular Pathology, Department of Pathology, O'Neal Cancer Center, University of Alabama, Heersink School of Medicine, Birmingham, United States of America
2UAB Biological Data Science Core, The University of Alabama at Birmingham, Birmingham, United States of America
3Division of Pharmacology, Chemistry and Biochemistry, College of Medicine, University of Arizona, Tucson, United States of America
4Department of Bioengineering, Indian Institute of Science, Bangalore, India
5Department of Medicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine, Pittsburgh, United States of America
6Department of Electrical and Computer Engineering, University of Delaware, Newark, United States of America
7Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, United States of America
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Published January 15, 2026 - More info
Copyright © 2026, Monavarian et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
