Resource and Technical AdvanceIn-Press PreviewBone biologyCell biologyDevelopment
Open Access | 
10.1172/jci.insight.191606
Aebp1 loss in osteoprogenitors leads to skeletal defects resembling Ehlers-Danlos Syndrome by diminishing Wnt/β-catenin signaling
Shuhao Feng,1 Zihang Feng,1 Zhonghao Deng,1 Yiran Wei,1 Ru Lian,1 Yangchen Jin,1 Shiqi Zhao,1 Yu Jin,1 Zhongmin Zhang,2 and Liang Zhao3
1Division of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China
2Division of Spine Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China
3Joint Surgery Department, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Find articles by Feng, S. in: PubMed | Google Scholar
1Division of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China
2Division of Spine Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China
3Joint Surgery Department, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Find articles by Feng, Z. in: PubMed | Google Scholar
1Division of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China
2Division of Spine Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China
3Joint Surgery Department, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Find articles by Deng, Z. in: PubMed | Google Scholar
1Division of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China
2Division of Spine Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China
3Joint Surgery Department, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Find articles by Wei, Y. in: PubMed | Google Scholar
1Division of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China
2Division of Spine Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China
3Joint Surgery Department, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Find articles by Lian, R. in: PubMed | Google Scholar
1Division of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China
2Division of Spine Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China
3Joint Surgery Department, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Find articles by Jin, Y. in: PubMed | Google Scholar
1Division of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China
2Division of Spine Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China
3Joint Surgery Department, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Find articles by Zhao, S. in: PubMed | Google Scholar
1Division of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China
2Division of Spine Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China
3Joint Surgery Department, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Find articles by Jin, Y. in: PubMed | Google Scholar
1Division of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China
2Division of Spine Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China
3Joint Surgery Department, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Find articles by Zhang, Z. in: PubMed | Google Scholar
1Division of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China
2Division of Spine Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China
3Joint Surgery Department, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Find articles by Zhao, L. in: PubMed | Google Scholar
Published November 13, 2025 - More info
Copyright © 2025, Feng et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
