In this video collection, authors of findings published in JCI Insight present personally guided tours of their results. The journal accepts video submissions from authors of recently accepted manuscripts. Instructions can be found on the Author's Take Guidelines page.
In this episode, Nardhy Gomez-Lopez explains that macrophages exert anti-inflammatory effects in late gestation, to maintain uterine quiescence and to protect against fetal inflammatory injury that compromises postnatal survival.
In this episode, Robert Blanton explains how this paper identifies mixed lineage kinase 3 as a novel PKG1a substrate. MLK3 mediates PKGI therapeutic effects on LV function but regulates blood pressure independently of PKG1.
In this episode, Joshua Hill explains that they investigated antibodies to vaccine-preventable infections and other pathogen-specific antibodies in individuals with remission after CAR-T-cell therapy for B-lineage malignancies.
In this episode, Cheryl Cero explains that β3-ARs in human brown/beige adipocytes are required to maintain multiple components of lipolytic and thermogenic cellular machinery and β3-AR agonists could be used to achieve metabolic benefit in humans.
In this episode, Helena Escobar and Simone Spuler explain that patient primary muscle stems cells gene repaired with greater than 90% efficiency by base editing maintain their regenerative properties for autologous cell replacement therapies of muscular dystrophy.