In this video collection, authors of findings published in JCI Insight present personally guided tours of their results. The journal accepts video submissions from authors of recently accepted manuscripts. Instructions can be found on the Author's Take Guidelines page.
In this episode, Joshua Hill explains that they investigated antibodies to vaccine-preventable infections and other pathogen-specific antibodies in individuals with remission after CAR-T-cell therapy for B-lineage malignancies.
In this episode, Cheryl Cero explains that β3-ARs in human brown/beige adipocytes are required to maintain multiple components of lipolytic and thermogenic cellular machinery and β3-AR agonists could be used to achieve metabolic benefit in humans.
In this episode, Helena Escobar and Simone Spuler explain that patient primary muscle stems cells gene repaired with greater than 90% efficiency by base editing maintain their regenerative properties for autologous cell replacement therapies of muscular dystrophy.
In this episode, Jane Buckner discusses how citrullinated tenascin-C is an autoantigen that is targeted by autoreactive CD4+ T cells and autoantibodies in patients with rheumatoid arthritis.
In this episode, Michel Bouvier explains the present study aimed at testing pharmacological chaperones in humanized MC4R mouses model as potential therapeutic treatment of melanocortin type 4 receptor linked obesity.