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Author's Take

In this video collection, authors of findings published in JCI Insight present personally guided tours of their results. The journal accepts video submissions from authors of recently accepted manuscripts. Instructions can be found on the Author's Take Guidelines page.

IsoLG adducts play an essential role in systemic lupus erythematosus

In this episode, David Patrick describes a new mechanism responsible for systemic lupus erythematosus (SLE). IsoLGs accumulate in cells of patients with lupus and lupus prone mice. Scavenging of IsoLGs attenuates autoimmunity and hypertension in lupus prone mice. IsoLGs adduct to and inhibit the activity of PU.1. This suppresses the transcription of C1q subunits.


Cilia proteins and altered flow in the vasculature

In this episode, Dr. Ramani Ramchandran explains that, in this study, the authors show that cilia on endothelial cells can disassemble under shear stress, and proteins from cilia can be tracked in fluids as a result of the disassembly process.


IDH1 mutation, histology, and treatment of tissue metabolites in diffuse glioma

In this episode, Ghazaleh Tabatabai and colleagues discuss the landscape of tissue metabolites and corresponding transcripts in diffuse glioma assessed by NMR metabolomics and RNA sequening.


Biological processes during term parturition

In this episode, Nardhy Gomez-Lopez explains how single-cell RNA-sequencing reveals the contributions of specific myometrial cell types to the biological processes implicated in term parturition.


Protection against preterm birth and fetal inflammatory injury

In this episode, Nardhy Gomez-Lopez explains that macrophages exert anti-inflammatory effects in late gestation, to maintain uterine quiescence and to protect against fetal inflammatory injury that compromises postnatal survival.

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