Author's Take
In this video collection, authors of findings published in JCI Insight present personally guided tours of their results. The journal accepts video submissions from authors of recently accepted manuscripts. Instructions can be found on the Author's Take Guidelines page.
In this episode, Costanza Lo Cascio, Artak Tovmasyan, and Shwetal Mehta discuss the identification of a brain-penetrant HDAC inhibitor with radiosensitizing properties for the treatment of glioblastoma.
In this episode, Ryan Gimple and colleagues explain that glioblastoma stem cells depend on SNX10, an endosomal protein sorting factor, which maintains cancer cell proliferation and stemness through platelet-derived growth factor receptor signaling.
In this episode, Kuppusamy Balamurugan and colleagues explain that COX-2 promotes E-Cadherin complex protein expression, and celecoxib in combination with paclitaxel diminishes cluster circulating tumor cells and established metastases in preclinical breast cancer models.
In this episode, the authors explain that fetal and maternal NLRP3 signaling participates in the intra-amniotic inflammatory response and common pathway of labor leading to premature parturition through inflammasome-associated and -independent mechanisms.
In this episode, Christopher Willey describes a panel of acquired radiation resistant GBM PDX and identifies potentially targetable transcriptomic (including lncRNA) and kinomic alterations.
