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Author's Take

In this video collection, authors of findings published in JCI Insight present personally guided tours of their results. The journal accepts video submissions from authors of recently accepted manuscripts. Instructions can be found on the Author's Take Guidelines page.

NLRP3 signaling and preterm labor and birth

In this episode, the authors explain that fetal and maternal NLRP3 signaling participates in the intra-amniotic inflammatory response and common pathway of labor leading to premature parturition through inflammasome-associated and -independent mechanisms.


Long noncoding RNAs and targetable kinases and glioblastoma radiation resistance

In this episode, Christopher Willey describes a panel of acquired radiation resistant GBM PDX and identifies potentially targetable transcriptomic (including lncRNA) and kinomic alterations.


FAM114A1 as a therapeutic target for the treatment of heart disease

In this episode, Peng Yao explains that FAM114A1 modulates cardiac fibrosis by regulating Ang II signaling and pharmacological inhibition of FAM114A1 is a therapeutic strategy for the treatment of heart disease.


IsoLG adducts play an essential role in systemic lupus erythematosus

In this episode, David Patrick describes a new mechanism responsible for systemic lupus erythematosus (SLE). IsoLGs accumulate in cells of patients with lupus and lupus prone mice. Scavenging of IsoLGs attenuates autoimmunity and hypertension in lupus prone mice. IsoLGs adduct to and inhibit the activity of PU.1. This suppresses the transcription of C1q subunits.


Cilia proteins and altered flow in the vasculature

In this episode, Dr. Ramani Ramchandran explains that, in this study, the authors show that cilia on endothelial cells can disassemble under shear stress, and proteins from cilia can be tracked in fluids as a result of the disassembly process.

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