Antagonism of vasopressin V2 receptor improves albuminuria at the early stage of diabetic nephropathy in a mouse model of type 2 diabetes
R El Boustany, C Taveau, C Chollet, G Velho… - Journal of Diabetes and …, 2017 - Elsevier
Aims Vasopressin is increased in diabetes and was shown to contribute to development of
diabetic nephropathy through V2 receptor (V2R) activation in an experimental model of type
1 diabetes. The role of V2R in type 2 diabetes remains undocumented. This study addresses
the issue in a mouse model of type 2 diabetes. Methods Male obese diabetic db/db mice
were treated for 12 weeks with a selective V2R antagonist (SR121463) and compared to
non-treated db/db and non-diabetic db/m mice. All animals were previously …
diabetic nephropathy through V2 receptor (V2R) activation in an experimental model of type
1 diabetes. The role of V2R in type 2 diabetes remains undocumented. This study addresses
the issue in a mouse model of type 2 diabetes. Methods Male obese diabetic db/db mice
were treated for 12 weeks with a selective V2R antagonist (SR121463) and compared to
non-treated db/db and non-diabetic db/m mice. All animals were previously …