HuMax-CD4: a fully human monoclonal anti-CD4 antibody for the treatment of psoriasis vulgaris
L Skov, K Kragballe, C Zachariae, ER Obitz… - Archives of …, 2003 - jamanetwork.com
Background Psoriasis is characterized by infiltration with mononuclear cells. Especially
activated memory CD4+ T cells are critical in the pathogenesis. Interaction between the CD4
receptor and the major histocompatibility complex class II molecule is important for T-cell
activation. Objective To test safety and efficacy of a fully human monoclonal anti-CD4
antibody (HuMax-CD4) in the treatment of psoriasis. Design Multicenter, double-blind,
placebo-controlled, randomized clinical trial. Patients Eighty-five patients with moderate to …
activated memory CD4+ T cells are critical in the pathogenesis. Interaction between the CD4
receptor and the major histocompatibility complex class II molecule is important for T-cell
activation. Objective To test safety and efficacy of a fully human monoclonal anti-CD4
antibody (HuMax-CD4) in the treatment of psoriasis. Design Multicenter, double-blind,
placebo-controlled, randomized clinical trial. Patients Eighty-five patients with moderate to …