Lymphoid organ hypertrophy is a hallmark of localized infection. During the inflammatory
response, massive changes in lymphocyte recirculation and turnover boost lymphoid organ
cellularity. Intriguingly, the exact nature of these changes remains undefined to date. Here,
we report that hypertrophy of Salmonella-infected Peyer's patches (PPs) ensues from a
global “shutdown” of lymphocyte egress, which traps recirculating lymphocytes in PPs.
Surprisingly, infection-induced lymphocyte sequestration did not require previously …