Aging in the hematopoietic system and the stem cell niche contributes to aging-associated
phenotypes of hematopoietic stem cells (HSCs), including leukemia and aging-associated
immune remodeling. Among others, the DNA damage theory of aging of HSCs is well
established, based on the detection of a significantly larger amount of γH2AX foci and a
higher tail moment in the comet assay, both initially thought to be associated with DNA
damage in aged HSCs compared with young cells, and bone marrow failure in animals …