[HTML][HTML] Mechanisms of tumor escape in the context of the T-cell-inflamed and the non-T-cell-inflamed tumor microenvironment

S Spranger - International immunology, 2016 - ncbi.nlm.nih.gov
International immunology, 2016ncbi.nlm.nih.gov
Checkpoint blockade therapy has been proven to be highly active across many cancer types
but emerging evidence indicates that the therapeutic benefit is limited to a subset of patients
in each cancer entity. The presence of CD8+ T cells within the tumor microenvironment or
the invasive margin of the tumor, as well as the up-regulation of PD-L1, have emerged to be
the most predictive biomarkers for clinical benefit in response to checkpoint inhibition.
Although the up-regulation of immune inhibitory mechanisms is one mechanism of immune …
Abstract
Checkpoint blockade therapy has been proven to be highly active across many cancer types but emerging evidence indicates that the therapeutic benefit is limited to a subset of patients in each cancer entity. The presence of CD8+ T cells within the tumor microenvironment or the invasive margin of the tumor, as well as the up-regulation of PD-L1, have emerged to be the most predictive biomarkers for clinical benefit in response to checkpoint inhibition. Although the up-regulation of immune inhibitory mechanisms is one mechanism of immune escape, commonly used by T-cell-inflamed tumors, exclusion of an anti-tumor specific T-cell infiltrate displays another even more potent mechanism of immune escape. This review will contrast the mechanisms of immunogenic, T-cell-inflamed, and the novel concept of non-immunogenic, non-T-cell-inflamed, adaptive immune escape.
ncbi.nlm.nih.gov