Vagotomy enhances experimental metastases of 4THMpc breast cancer cells and alters substance P level
N Erin, GA Barkan, JF Harms, GA Clawson - Regulatory peptides, 2008 - Elsevier
We have previously demonstrated that inactivation of capsaicin-sensitive sensory neurons
enhances lung and heart metastases of breast carcinoma. Because a significant part of
sensory innervation of lung tissue is supplied by the vagus nerve, we here examined the
effects of unilateral mid-cervical vagotomy in the metastases of 4THMpc breast carcinoma
and tissue Substance P (SP) levels. Balb-c mice were injected orthotopically with 4THMpc
cells 1 week after vagotomy. Animals were sacrificed 27–30 days after injection of 4THMpc …
enhances lung and heart metastases of breast carcinoma. Because a significant part of
sensory innervation of lung tissue is supplied by the vagus nerve, we here examined the
effects of unilateral mid-cervical vagotomy in the metastases of 4THMpc breast carcinoma
and tissue Substance P (SP) levels. Balb-c mice were injected orthotopically with 4THMpc
cells 1 week after vagotomy. Animals were sacrificed 27–30 days after injection of 4THMpc …
