[HTML][HTML] Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes
W Chen, RL Hoo, M Konishi, N Itoh, P Lee, H Ye… - Journal of Biological …, 2011 - ASBMB
Fibroblast growth factor (FGF) 21 and growth hormone (GH) are metabolic hormones that
play important roles in regulating glucose and lipid metabolism. Both hormones are induced
in response to fasting and exert their actions on adipocytes to regulate lipolysis. However,
the molecular interaction between these two hormones remains unclear. Here we
demonstrate the existence of a feedback loop between GH and FGF21 on the regulation of
lipolysis in adipocytes. A single bolus injection of GH into C57 mice acutely increases both …
play important roles in regulating glucose and lipid metabolism. Both hormones are induced
in response to fasting and exert their actions on adipocytes to regulate lipolysis. However,
the molecular interaction between these two hormones remains unclear. Here we
demonstrate the existence of a feedback loop between GH and FGF21 on the regulation of
lipolysis in adipocytes. A single bolus injection of GH into C57 mice acutely increases both …