[HTML][HTML] Assessment of pain and itch behavior in a mouse model of neurofibromatosis type 1
DE O'Brien, DS Brenner, DH Gutmann, RW Gereau IV - The journal of pain, 2013 - Elsevier
Neurofibromatosis type 1 (NF1) is characterized primarily by tumor formation in the nervous
system, but patients report other neurological complications including pain and itch.
Individuals with NF1 harbor 1 mutated NF1 allele causing heterozygous expression in all of
their cells. In mice, Nf1 heterozygosity leads to hyperexcitability of sensory neurons and
hyperproliferation of mast cells, both of which could lead to increased hypersensitivity and
scratching in response to noxious and pruritic stimuli. To determine whether Nf1 …
system, but patients report other neurological complications including pain and itch.
Individuals with NF1 harbor 1 mutated NF1 allele causing heterozygous expression in all of
their cells. In mice, Nf1 heterozygosity leads to hyperexcitability of sensory neurons and
hyperproliferation of mast cells, both of which could lead to increased hypersensitivity and
scratching in response to noxious and pruritic stimuli. To determine whether Nf1 …