TGF-α mediates genetic susceptibility to chronic kidney disease
D Laouari, M Burtin, A Phelep, C Martino… - Journal of the …, 2011 - journals.lww.com
The mechanisms of progression of chronic kidney disease (CKD) are poorly understood.
Epidemiologic studies suggest a strong genetic component, but the genes that contribute to
the onset and progression of CKD are largely unknown. Here, we applied an experimental
model of CKD (75% excision of total renal mass) to six different strains of mice and found
that only the FVB/N strain developed renal lesions. We performed a genome-scan analysis
in mice generated by back-crossing resistant and sensitive strains; we identified a major …
Epidemiologic studies suggest a strong genetic component, but the genes that contribute to
the onset and progression of CKD are largely unknown. Here, we applied an experimental
model of CKD (75% excision of total renal mass) to six different strains of mice and found
that only the FVB/N strain developed renal lesions. We performed a genome-scan analysis
in mice generated by back-crossing resistant and sensitive strains; we identified a major …