Endothelial Krüppel-like factor 4 mediates the protective effect of statins against ischemic AKI
T Yoshida, M Yamashita, M Iwai… - Journal of the American …, 2016 - journals.lww.com
Endothelial cells participate in the pathophysiology of ischemic AKI by increasing the
expression of cell adhesion molecules and by recruiting inflammatory cells. We previously
showed that endothelial Krüppel-like factor 4 (Klf4) regulates vascular cell adhesion
molecule 1 (Vcam1) expression and neointimal formation after carotid injury. In this study,
we determined whether endothelial Klf4 is involved in ischemic AKI using endothelial Klf4
conditional knockout (Klf4 cKO) mice generated by breeding Tek-Cre mice and Klf4 floxed …
expression of cell adhesion molecules and by recruiting inflammatory cells. We previously
showed that endothelial Krüppel-like factor 4 (Klf4) regulates vascular cell adhesion
molecule 1 (Vcam1) expression and neointimal formation after carotid injury. In this study,
we determined whether endothelial Klf4 is involved in ischemic AKI using endothelial Klf4
conditional knockout (Klf4 cKO) mice generated by breeding Tek-Cre mice and Klf4 floxed …