[HTML][HTML] Krüppel-like factor 4 (gut-enriched Krüppel-like factor) inhibits cell proliferation by blocking G1/S progression of the cell cycle
X Chen, DC Johns, DE Geiman, E Marban… - Journal of Biological …, 2001 - ASBMB
Krüppel-like factor 4 (KLF4) is an epithelial cell-enriched, zinc finger-containing
transcription factor, the expression of which is associated with growth arrest. Previous
studies show that constitutive expression of KLF4 inhibits DNA synthesis but the manner by
which KLF4 exerts this effect is unclear. In the present study, we developed a system in
which expression of KLF4 is controlled by a promoter that is induced upon treatment of cells
containing the receptors for the insect hormone, ecdysone, with ponasterone A, an …
transcription factor, the expression of which is associated with growth arrest. Previous
studies show that constitutive expression of KLF4 inhibits DNA synthesis but the manner by
which KLF4 exerts this effect is unclear. In the present study, we developed a system in
which expression of KLF4 is controlled by a promoter that is induced upon treatment of cells
containing the receptors for the insect hormone, ecdysone, with ponasterone A, an …