Cellular lesions form in Bowman's space in both crescentic glomerulonephritis and
collapsing glomerulopathy. The pathomechanism and origin of the proliferating cells in
these lesions are unknown. In this study, we examined proliferating cells by lineage tracing
of either podocytes or parietal epithelial cells (PECs) in the nephrotoxic nephritis model of
inflammatory crescentic glomerulonephritis. In addition, we traced the fate of genetically
labeled PECs in the Thy-1.1 transgenic mouse model of collapsing glomerulopathy. In both …