Pathologic classification of focal segmental glomerulosclerosis: a working proposal

VD D'Agati, AB Fogo, JA Bruijn, JC Jennette - American journal of kidney …, 2004 - ajkd.org
IN 1957, ARNOLD RICH1 described segmen-tal sclerosis involving juxtamedullary
glomeruli in autopsy specimens of children dying of nephrotic syndrome caused by apparent
lipoid nephrosis. He hypothesized that the development of glomerulosclerosis accounted for
the progression to renal failure seen in a subset of children with idiopathic nephrotic
syndrome. However, it was not until the 1970s, in a report by the International Study of
Kidney Diseases in Children, that focal segmental glomerulosclerosis (FSGS) emerged as a …