[HTML][HTML] Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA
TD Kanneganti, M Body-Malapel, A Amer… - Journal of Biological …, 2006 - ASBMB
Viral infection induces the production of interleukin (IL)-1β and IL-18 in macrophages
through the activation of caspase-1, but the mechanism by which host cells sense viruses to
induce caspase-1 activation is unknown. In this report, we have identified a signaling
pathway leading to caspase-1 activation that is induced by double-stranded RNA (dsRNA)
and viral infection that is mediated by Cryopyrin/Nalp3. Stimulation of macrophages with
dsRNA, viral RNA, or its analog poly (I: C) induced the secretion of IL-1β and IL-18 in a …
through the activation of caspase-1, but the mechanism by which host cells sense viruses to
induce caspase-1 activation is unknown. In this report, we have identified a signaling
pathway leading to caspase-1 activation that is induced by double-stranded RNA (dsRNA)
and viral infection that is mediated by Cryopyrin/Nalp3. Stimulation of macrophages with
dsRNA, viral RNA, or its analog poly (I: C) induced the secretion of IL-1β and IL-18 in a …