Immune cells express receptors for extracellular nucleotides named P2 receptors. P2
receptors transduce signals delivered by nucleotides present in the extracellular
environment. Accruing evidence shows that purinergic signalling has a profound effect on
multiple immune cell responses such as T lymphocyte proliferation, chemotaxis, cytokine
release, phagocytosis, Ag presentation and cytotoxicity. This makes P2 receptors an
attractive target for the therapy of immuno-mediated disease and cancer.