Aberrant expression of the costimulatory molecule CD40 ligand on monocytes from patients with systemic lupus erythematosus
CG Katsiari, SNC Liossis, VL Souliotis… - Clinical …, 2002 - Elsevier
CD40 ligand (CD40L, CD154) is overexpressed on T and B cells in systemic lupus
erythematosus (SLE). Monocytes have been shown to contribute to immune-mediated
pathology in SLE and to express CD40L under certain conditions. Therefore, we studied
CD40L expression on lupus monocytes ex vivo, as well as after activation in vitro. A highly
significant sevenfold increase in the frequency of CD40L-expressing peripheral monocytes
from 23 SLE patients, compared to 16 healthy individuals (mean percentage of CD40L+ …
erythematosus (SLE). Monocytes have been shown to contribute to immune-mediated
pathology in SLE and to express CD40L under certain conditions. Therefore, we studied
CD40L expression on lupus monocytes ex vivo, as well as after activation in vitro. A highly
significant sevenfold increase in the frequency of CD40L-expressing peripheral monocytes
from 23 SLE patients, compared to 16 healthy individuals (mean percentage of CD40L+ …