[HTML][HTML] Loss of hepatic AMP-activated protein kinase impedes the rate of glycogenolysis but not gluconeogenic fluxes in exercising mice
CC Hughey, FD James, DP Bracy, EP Donahue… - Journal of Biological …, 2017 - ASBMB
Pathologies including diabetes and conditions such as exercise place an unusual demand
on liver energy metabolism, and this demand induces a state of energy discharge. Hepatic
AMP-activated protein kinase (AMPK) has been proposed to inhibit anabolic processes such
as gluconeogenesis in response to cellular energy stress. However, both AMPK activation
and glucose release from the liver are increased during exercise. Here, we sought to test the
role of hepatic AMPK in the regulation of in vivo glucose-producing and citric acid cycle …
on liver energy metabolism, and this demand induces a state of energy discharge. Hepatic
AMP-activated protein kinase (AMPK) has been proposed to inhibit anabolic processes such
as gluconeogenesis in response to cellular energy stress. However, both AMPK activation
and glucose release from the liver are increased during exercise. Here, we sought to test the
role of hepatic AMPK in the regulation of in vivo glucose-producing and citric acid cycle …