[HTML][HTML] Role of the microbiota and antibiotics in primary sclerosing cholangitis

JH Tabibian, JA Talwalkar, KD Lindor - BioMed research …, 2013 - hindawi.com
JH Tabibian, JA Talwalkar, KD Lindor
BioMed research international, 2013hindawi.com
Primary sclerosing cholangitis (PSC) is an idiopathic, progressive, cholestatic liver disease
with considerable morbidity and mortality and no established pharmacotherapy. In addition
to the long-recognized association between PSC and inflammatory bowel disease, several
lines of preclinical and clinical evidence implicate the microbiota in the etiopathogenesis of
PSC. Here we provide a concise review of these data which, taken together, support further
investigation of the role of the microbiota and antibiotics in PSC as potential avenues toward …
Primary sclerosing cholangitis (PSC) is an idiopathic, progressive, cholestatic liver disease with considerable morbidity and mortality and no established pharmacotherapy. In addition to the long-recognized association between PSC and inflammatory bowel disease, several lines of preclinical and clinical evidence implicate the microbiota in the etiopathogenesis of PSC. Here we provide a concise review of these data which, taken together, support further investigation of the role of the microbiota and antibiotics in PSC as potential avenues toward elucidating safe and effective pharmacotherapy for patients afflicted by this illness.
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