The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies
LA Adams, S Sanderson, KD Lindor, P Angulo - Journal of hepatology, 2005 - Elsevier
BACKGROUND/AIMS: The histological course of nonalcoholic fatty liver disease (NAFLD)
remains undescribed. Therefore, we examined the liver histology of NAFLD patients who
had undergone sequential liver biopsies. METHODS: Data on 103 patients who underwent
serial liver biopsies in the absence of effective treatment were reviewed, and biopsies
scored in a blind fashion. RESULTS: Mean interval between biopsies was 3.2±3.0 years
(range 0.7–21.3). Fibrosis stage apparently progressed in 37%, remained stable in 34% and …
remains undescribed. Therefore, we examined the liver histology of NAFLD patients who
had undergone sequential liver biopsies. METHODS: Data on 103 patients who underwent
serial liver biopsies in the absence of effective treatment were reviewed, and biopsies
scored in a blind fashion. RESULTS: Mean interval between biopsies was 3.2±3.0 years
(range 0.7–21.3). Fibrosis stage apparently progressed in 37%, remained stable in 34% and …