[HTML][HTML] Exploitation of the polymeric immunoglobulin receptor for antibody targeting to renal cyst lumens in polycystic kidney disease
Autosomal-dominant polycystic kidney disease (ADPKD) is a common life-threatening
genetic disease that leads to renal failure. No treatment is available yet to effectively slow
disease progression. Renal cyst growth is, at least in part, driven by the presence of growth
factors in the lumens of renal cysts, which are enclosed spaces lacking connections to the
tubular system. We have shown previously shown that IL13 in cyst fluid leads to aberrant
activation of STAT6 via the IL4/13 receptor. Although antagonistic antibodies against many …
genetic disease that leads to renal failure. No treatment is available yet to effectively slow
disease progression. Renal cyst growth is, at least in part, driven by the presence of growth
factors in the lumens of renal cysts, which are enclosed spaces lacking connections to the
tubular system. We have shown previously shown that IL13 in cyst fluid leads to aberrant
activation of STAT6 via the IL4/13 receptor. Although antagonistic antibodies against many …