The role of natural IgM in myocardial ischemia–reperfusion injury

M Zhang, LH Michael, SA Grosjean, RA Kelly… - Journal of molecular and …, 2006 - Elsevier
M Zhang, LH Michael, SA Grosjean, RA Kelly, MC Carroll, ML Entman
Journal of molecular and cellular cardiology, 2006Elsevier
Myocardial ischemia–reperfusion injury represents a combination of factors, namely the
intrinsic cellular response to ischemia and the extrinsic acute inflammatory response.
Recent studies in mesenteric and skeletal muscle reperfusion models identified natural IgM
as a major initiator of pathology through the activation of the complement system and
inflammatory cells. To determine whether a similar mechanism is involved in myocardial
tissues, mice bearing an altered natural IgM repertoire (Cr2−/−) were examined in a murine …
Myocardial ischemia–reperfusion injury represents a combination of factors, namely the intrinsic cellular response to ischemia and the extrinsic acute inflammatory response. Recent studies in mesenteric and skeletal muscle reperfusion models identified natural IgM as a major initiator of pathology through the activation of the complement system and inflammatory cells. To determine whether a similar mechanism is involved in myocardial tissues, mice bearing an altered natural IgM repertoire (Cr2−/−) were examined in a murine model of coronary artery ischemia. Notably, these mice were significantly protected based on the reduced infarct size, limited apoptosis of cardiomyocytes, and decreased neutrophil infiltration. Protection was IgM-dependent as reconstitution of these mice with wild-type IgM restored myocardial reperfusion injury. These results support a model in which natural IgM initiates the acute inflammatory response in the myocardium following ischemia and reperfusion.
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