Association between lowering LDL-C and cardiovascular risk reduction among different therapeutic interventions: a systematic review and meta-analysis
MG Silverman, BA Ference, K Im, SD Wiviott… - Jama, 2016 - jamanetwork.com
Importance The comparative clinical benefit of nonstatin therapies that reduce low-density
lipoprotein cholesterol (LDL-C) remains uncertain. Objective To evaluate the association
between lowering LDL-C and relative cardiovascular risk reduction across different statin
and nonstatin therapies. Data Sources and Study Selection The MEDLINE and EMBASE
databases were searched (1966-July 2016). The key inclusion criteria were that the study
was a randomized clinical trial and the reported clinical outcomes included myocardial …
lipoprotein cholesterol (LDL-C) remains uncertain. Objective To evaluate the association
between lowering LDL-C and relative cardiovascular risk reduction across different statin
and nonstatin therapies. Data Sources and Study Selection The MEDLINE and EMBASE
databases were searched (1966-July 2016). The key inclusion criteria were that the study
was a randomized clinical trial and the reported clinical outcomes included myocardial …
