A role for tubular necroptosis in cisplatin-induced AKI
Cell death and inflammation in the proximal tubules are the hallmarks of cisplatin-induced
AKI, but the mechanisms underlying these effects have not been fully elucidated. Here, we
investigated whether necroptosis, a type of programmed necrosis, has a role in cisplatin-
induced AKI. We found that inhibition of any of the core components of the necroptotic
pathway—receptor-interacting protein 1 (RIP1), RIP3, or mixed lineage kinase domain-like
protein (MLKL)—by gene knockout or a chemical inhibitor diminished cisplatin-induced …
AKI, but the mechanisms underlying these effects have not been fully elucidated. Here, we
investigated whether necroptosis, a type of programmed necrosis, has a role in cisplatin-
induced AKI. We found that inhibition of any of the core components of the necroptotic
pathway—receptor-interacting protein 1 (RIP1), RIP3, or mixed lineage kinase domain-like
protein (MLKL)—by gene knockout or a chemical inhibitor diminished cisplatin-induced …
