[HTML][HTML] CpG DNA-mediated induction of acute liver injury in D-galactosamine-sensitized mice: the mitochondrial apoptotic pathway-dependent death of hepatocytes
AK Yi, H Yoon, JE Park, BS Kim, HJ Kim… - Journal of Biological …, 2006 - ASBMB
Unmethylated CpG motifs present in bacterial DNA (CpG DNA) induce innate inflammatory
responses, including rapid induction of proinflammatory cytokines. Although innate
inflammatory responses induced by CpG DNA and other pathogen-associated molecular
patterns are essential for the eradication of infectious microorganisms, excessive activation
of innate immunity is detrimental to the host. In this study, we demonstrate that CpG DNA, but
not control non-CpG DNA, induces a fulminant liver failure with subsequent shock-mediated …
responses, including rapid induction of proinflammatory cytokines. Although innate
inflammatory responses induced by CpG DNA and other pathogen-associated molecular
patterns are essential for the eradication of infectious microorganisms, excessive activation
of innate immunity is detrimental to the host. In this study, we demonstrate that CpG DNA, but
not control non-CpG DNA, induces a fulminant liver failure with subsequent shock-mediated …