[HTML][HTML] Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL

WJ Kaiser, H Sridharan, C Huang, P Mandal… - Journal of Biological …, 2013 - ASBMB
Toll-like receptor (TLR) signaling is triggered by pathogen-associated molecular patterns
that mediate well established cytokine-driven pathways, activating NF-κB together with
IRF3/IRF7. In addition, TLR3 drives caspase 8-regulated programmed cell death pathways
reminiscent of TNF family death receptor signaling. We find that inhibition or elimination of
caspase 8 during stimulation of TLR2, TLR3, TLR4, TLR5, or TLR9 results in receptor
interacting protein (RIP) 3 kinase-dependent programmed necrosis that occurs through …