CSF-1/CSF-1R targeting agents in clinical development for cancer therapy
CH Ries, S Hoves, MA Cannarile, D Rüttinger - Current opinion in …, 2015 - Elsevier
Highlights•TAM promote tumor growth and efficiently suppress immune effector
cells.•Targeting TAM via the CSF-1/CSF-1R pathway is an attractive therapy for cancer.•Can
in vitro differentiated macrophages reflect patient-derived TAM?•TAM depletion combined
with standard-or immuno-therapies will be the way forward.Macrophage infiltration has been
identified as an independent poor prognostic factor for several cancer entities. In mouse
tumor models macrophages orchestrate various tumor-promoting processes. This …
cells.•Targeting TAM via the CSF-1/CSF-1R pathway is an attractive therapy for cancer.•Can
in vitro differentiated macrophages reflect patient-derived TAM?•TAM depletion combined
with standard-or immuno-therapies will be the way forward.Macrophage infiltration has been
identified as an independent poor prognostic factor for several cancer entities. In mouse
tumor models macrophages orchestrate various tumor-promoting processes. This …