[HTML][HTML] The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest
E Shaulian, M Schreiber, F Piu, M Beeche, EF Wagner… - Cell, 2000 - cell.com
The mammalian UV response results in rapid and dramatic induction of c-jun. Induction of a
protooncogene, normally involved in mitogenic responses, by a genotoxic agent that causes
growth arrest seems paradoxical. We now provide an explanation for the role of c-Jun in the
UV response of mouse fibroblasts. c-Jun is necessary for cell-cycle reentry of UV-irradiated
cells, but does not participate in the response to ionizing radiation. Cells lacking c-Jun
undergo prolonged cell-cycle arrest, but resist apoptosis, whereas cells that express c-Jun …
protooncogene, normally involved in mitogenic responses, by a genotoxic agent that causes
growth arrest seems paradoxical. We now provide an explanation for the role of c-Jun in the
UV response of mouse fibroblasts. c-Jun is necessary for cell-cycle reentry of UV-irradiated
cells, but does not participate in the response to ionizing radiation. Cells lacking c-Jun
undergo prolonged cell-cycle arrest, but resist apoptosis, whereas cells that express c-Jun …
Abstract
The mammalian UV response results in rapid and dramatic induction of c-jun. Induction of a protooncogene, normally involved in mitogenic responses, by a genotoxic agent that causes growth arrest seems paradoxical. We now provide an explanation for the role of c-Jun in the UV response of mouse fibroblasts. c-Jun is necessary for cell-cycle reentry of UV-irradiated cells, but does not participate in the response to ionizing radiation. Cells lacking c-Jun undergo prolonged cell-cycle arrest, but resist apoptosis, whereas cells that express c-Jun constitutively do not arrest and undergo apoptosis. This function of c-Jun is exerted through negative regulation of p53 association with the p21 promoter. Cells lacking c-Jun exhibit prolonged p21 induction, whereas constitutive c-Jun inhibits UV-mediated p21 induction.
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